Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.57 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.53 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | SRC | P12931 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL965912 | 1.00 | EPHX1 (0.57) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| SCHEMBL9705 | 1.00 | EPHX1 (0.57) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| Hydrochloric Acid SCHEMBL29096650 | 0.98 | EPHX1 (0.55) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| Water SCHEMBL27340802 | 0.98 | EPHX1 (0.55) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| Hydrochloric Acid SCHEMBL3308273 | 0.98 | EPHX1 (0.55) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| Cyclopropane SCHEMBL27764666 | 0.94 | EPHX1 (0.52) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| SCHEMBL27522920 | 0.94 | PTGS2 (0.62) | EPHX1ALOX5PTGS2LMNAHIF1A | |
| Hypophosphorous Acid SCHEMBL31007070 | 0.92 | EPHX1 (0.50) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| Benzoic Acid SCHEMBL28452765 | 0.90 | TSHR (0.54) | EPHX1ALOX5PTGS2POLBTRPM8 | |
| Trifluoroacetic Acid SCHEMBL6756447 | 0.88 | EPHX1 (0.51) | EPHX1ALOX5PTGS2POLBTRPM8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 106 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7985760-B2 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | ACTELION PHARMACEUTICALS LTD. (CH) | 2011-07-26 | — | — | US | claimed |
| US-20110144033-A1 | Proteasome Inhibitors and Methods of Using the Same | CEPHALON, INC. (US) | 2011-06-16 | — | — | US | claimed |
| US-7915236-B2 | Proteasome inhibitors and methods of using the same | CEPHALON, INC. (US) | 2011-03-29 | — | — | US | claimed |
| EP-1660507-B9 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2010-03-24 | — | — | EP | claimed |
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2009-11-26 | — | — | US | claimed |
| EP-1660507-B1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON INC (US) | 2009-08-05 | — | — | EP | claimed |
| EP-1660507-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2006-05-31 | — | — | EP | claimed |
| US-20060058349-A1 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | OXFORD GLYCOSCIENCES(UK) LTD (GB) | 2006-03-16 | — | — | US | claimed |
| US-20050107307-A1 | Proteasome inhibitors and methods of using the same | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2005-05-19 | — | — | US | claimed |
| WO-2005021558-A2 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | CEPHALON, INC. (US) | 2005-03-10 | — | — | WO | claimed |
| CN-113735730-B | Preparation method of acyl primary amine | 广州大学 | 2023-11-28 | — | — | CN | disclosed |
| CN-111757940-B | Microbiological method for producing amides | 哥伦比亚有限公司 | 2023-11-07 | — | — | CN | disclosed |
| WO-2023102507-A1 | MACROCYCLIC IMMUNOMODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-06-08 | — | — | WO | disclosed |
| EP-3710592-B1 | MICROBIOLOGICAL PROCESS FOR THE PREPARATION OF AMIDES | COLUMBIA S R L (IT) | 2022-08-31 | — | — | EP | disclosed |
| US-11261468-B2 | Microbiological process for the preparation of amides | COLUMBIA SRL (IT) | 2022-03-01 | — | — | US | disclosed |
| CN-1419536-A | Process for the selective N-formylation of n-hydroxylamines | ABBOTT LAB (US) | 2003-05-21 | — | — | CN | disclosed |
| US-20030049807-A1 | Micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | INSTITUTO BIOCHIMICO ITALIANO GIOVANNI LOREZINI S.P.A. (IT) | 2003-03-13 | — | — | US | disclosed |
| EP-1291435-A2 | A micro-organism possessing enantioselective and regioselective nitrile hydratase/amidase activities | ISTITUTO BIOCHIMICO ITALIANO GIOVANNI LORENZINI S.p.A. (IT) | 2003-03-12 | — | — | EP | disclosed |
| US-6281003-B1 | REACTING RACEMIC AMIDE, CARBOXYLIC ACID OR ESTER WITH HYDROXYLAMINE | FRAUNHOFER-GESELLSCHAFT ZUR FORDERUNG DER ANGEWANDTEN FORSCHUNG E. V. (DE) | 2001-08-28 | — | — | US | disclosed |
| US-5258305-A | Manufacture of optically active 2-phenylpropionic acid and 2-phenylpropionamide from the nitrile using Rhodococcus equi | NITTO CHEMICAL INDUSTRY CO., LTD. (JP) | 1993-11-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090291918-A1 | PROTEASOME INHIBITORS AND METHODS OF USING THE SAME | PSMB11, PSMB5, PSMB6 | EPHX1 2993/4885ALOX5 2283/4885PTGS2 3653/4885 |
| US-20050107307-A1 | Proteasome inhibitors and methods of using the same | PSMB11, PSMB5, PSMB6 | EPHX1 2993/4885ALOX5 2283/4885PTGS2 3653/4885 |
| US-20060058349-A1 | Piperidinetriol derivatives as inhibitors of glycosyceramid synthase | CERS2, UGCG, GBA1 | EPHX1 1594/4885ALOX5 1843/4885PTGS2 1154/4885 |
| US-20110144033-A1 | Proteasome Inhibitors and Methods of Using the Same | PSMB11, PSMB5, PSMB6 | EPHX1 2993/4885ALOX5 2283/4885PTGS2 3653/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.