Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 10/20 | 0.47 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5454450 | 0.92 | PRKDC (0.48) | PRKDCMAOAPOLBALDH1A1LMNA | |
| SCHEMBL14802153 | 0.86 | PRKDC (0.61) | PRKDCPOLB | |
| SCHEMBL5440522 | 0.85 | PRKDC (0.48) | PRKDCPOLBALDH1A1LMNAGAA | |
| SCHEMBL14802150 | 0.84 | PRKDC (0.48) | PRKDCMAOAALDH1A1GAAMAPT | |
| SCHEMBL14447675 | 0.82 | PRKDC (0.49) | PRKDCMAOAALDH1A1GAAMAPT | |
| SCHEMBL14468611 | 0.81 | PRKDC (0.43) | PRKDC | |
| SCHEMBL14802154 | 0.80 | PRKDC (0.46) | PRKDC | |
| SCHEMBL5454455 | 0.80 | PRKDC (0.44) | PRKDCMAOAPOLBGAA | |
| SCHEMBL5444190 | 0.79 | PRKDC (0.56) | PRKDCMAOAGAAMAPTL3MBTL1 | |
| SCHEMBL5448696 | 0.78 | PRKDC (0.61) | PRKDCCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404681-B2 | Xanthones, thioxanthones and acridinones as DNA-PK inhibitors | LUITPOLD PHARMACEUTICALS, INC. (US) | 2013-03-26 | — | — | US | disclosed |