Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | PPARD | Q03181 | 2/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | PTGDR2 | Q9Y5Y4 | 7/20 | 0.40 |
| ▸ | PTGDR | Q13258 | 6/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.39 |
| ▸ | THRA | P10827 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12627990 | 0.86 | GAA (0.52) | CA2PTGDR2GAAALDH1A1TDP1 | |
| SCHEMBL12628082 | 0.85 | GAA (0.42) | PTGDR2PTGDRFFAR1GAAALDH1A1 | |
| SCHEMBL13742641 | 0.80 | FFAR1 (0.56) | CA2PPARDCHRM1PTGDR2FFAR1 | |
| SCHEMBL2006729 | 0.78 | PDE7A (0.47) | CA2PPARDCHRM1PTGDR2PTGDR | |
| SCHEMBL11290861 | 0.76 | PTGDR2 (0.34) | PTGDR2GAAALDH1A1TDP1TSHR | |
| SCHEMBL12627991 | 0.73 | CTSD (0.48) | GAAALDH1A1TDP1TSHRNFKB1 | |
| SCHEMBL13742135 | 0.72 | MAPT (0.42) | ALDH1A1TSHRNFKB1POLBHPGD | |
| SCHEMBL27895980 | 0.71 | GAA (0.64) | GAAALDH1A1TDP1TSHRNFKB1 | |
| SCHEMBL921998 | 0.70 | GAA (0.68) | CA2PPARDGAAALDH1A1TDP1 | |
| SCHEMBL13742690 | 0.69 | L3MBTL1 (0.41) | ALDH1A1TSHRNFKB1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2164828-B1 | COMPOUNDS AS CRTH2 AND/OR PGD2 RECEPTORS MODULATORS AND THEIR USE FOR TREATING ASTHMA AND ALLERGIC INFLAMMATION | AMGEN INC (US) | 2013-03-27 | — | — | EP | disclosed |