Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.56 |
| ▸ | TRPM8 | Q7Z2W7 | 10/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14821835 | 1.00 | ALDH1A1 (0.56) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14821573 | 0.90 | NPC1 (0.53) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14821582 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14821554 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14821580 | 0.86 | ALDH1A1 (0.57) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14821822 | 0.86 | ALDH1A1 (0.59) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL15276639 | 0.85 | TRPM8 (0.64) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL15276640 | 0.85 | TRPM8 (0.64) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14821893 | 0.83 | ALDH1A1 (0.56) | ALDH1A1TRPM8NPC1LMNAMAPT | |
| SCHEMBL14822027 | 0.82 | ALDH1A1 (0.55) | ALDH1A1TRPM8NPC1LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013041621-A1 | LOW MOLECULAR WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 AND USE THEREOF | BASF SE (DE) | 2013-03-28 | — | — | WO | disclosed |