Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | KIF11 | P52732 | 1/20 | 0.37 |
| ▸ | HTR2C | P28335 | 8/20 | 0.35 |
| ▸ | HTR2A | P28223 | 7/20 | 0.35 |
| ▸ | HTR2B | P41595 | 4/20 | 0.35 |
| ▸ | PKLR | P30613 | 1/20 | 0.33 |
| ▸ | FABP4 | P15090 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | IDH1 | O75874 | 1/20 | 0.32 |
| ▸ | DRD1 | P21728 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.31 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14405274 | 0.90 | HTR2C (0.38) | HTR2CHTR2AHTR2BMTNR1AMTNR1B | |
| SCHEMBL14824928 | 0.89 | HTR2C (0.35) | HTR2CHTR2AHTR2BALDH1A1GAA | |
| SCHEMBL11996624 | 0.79 | MAOA (0.41) | MAOAMAOBKIF11HTR2CHTR2A | |
| SCHEMBL20741822 | 0.78 | HTR2A (0.43) | MAOBKIF11HTR2CHTR2AHTR2B | |
| SCHEMBL30949613 | 0.78 | HTR2A (0.43) | MAOBKIF11HTR2CHTR2AHTR2B | |
| SCHEMBL3716928 | 0.76 | ALOX5 (0.39) | MAOAMAOBKIF11HTR2CHTR2A | |
| SCHEMBL5546114 | 0.76 | MAOA (0.42) | MAOAMAOBKIF11HTR2CHTR2A | |
| SCHEMBL26230379 | 0.76 | MAOA (0.39) | MAOAMAOBKIF11HTR2CHTR2A | |
| SCHEMBL21603512 | 0.76 | MAOA (0.39) | MAOAMAOBKIF11HTR2CHTR2A | |
| SCHEMBL5546117 | 0.76 | MAOA (0.46) | MAOAMAOBKIF11HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2757096-A9 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2014-11-26 | — | — | EP | disclosed |
| EP-2757096-A1 | Inhibitors of human immunodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2014-07-23 | — | — | EP | disclosed |
| EP-2220046-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | GILEAD SCIENCES INC (US) | 2014-06-18 | — | — | EP | disclosed |
| EP-2220084-B1 | INHIBITORS OF HUMAN IMMUNODEFICIENCY VIRUS REPLICATION | GILEAD SCIENCES INC (US) | 2014-02-19 | — | — | EP | disclosed |
| EP-2574610-A1 | Inhibitors of human immonodeficiency virus replication | GILEAD SCIENCES, INC. (US) | 2013-04-03 | — | — | EP | disclosed |