Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 5/20 | 0.42 |
| ▸ | GNRHR | P30968 | 5/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14828557 | 0.86 | LMNA (0.40) | PTGDR2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL2831862 | 0.85 | CNR2 (0.46) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL2832433 | 0.85 | LMNA (0.38) | MAPTKDM4EALDH1A1KMT2AMEN1 | |
| SCHEMBL14828548 | 0.84 | PTGDR2 (0.47) | PTGDR2TP53MAPT | |
| SCHEMBL2308886 | 0.84 | MEN1 (0.48) | PTGDR2TP53KDM4EKMT2AMEN1 | |
| SCHEMBL14828516 | 0.83 | RORC (0.42) | PTGDR2MAPTALDH1A1KMT2AMEN1 | |
| SCHEMBL3346327 | 0.83 | MAPT (0.43) | TP53MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL14828518 | 0.83 | MEN1 (0.34) | PTGDR2TP53KMT2AMEN1ATM | |
| SCHEMBL3379736 | 0.83 | MEN1 (0.34) | PTGDR2MAPTKDM4EALDH1A1KMT2A | |
| SCHEMBL2313628 | 0.83 | HTR2A (0.36) | GNRHRALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415373-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | claimed |
| US-8415373-B2 | Isoquinolinone derivatives as NK3 antagonists | H. LUNDBECK A/S (DK) | 2013-04-09 | — | — | US | disclosed |