Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 | P11229 | 7/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1482313 | 0.84 | CHRM1 (0.57) | CHRM1LMNAMAPTKDM4ETSHR | |
| SCHEMBL1482526 | 0.83 | CHRM1 (0.56) | CHRM1LMNAMAPTKDM4ETSHR | |
| SCHEMBL1481866 | 0.83 | CHRM1 (0.55) | CHRM1LMNAMAPTKDM4ETSHR | |
| SCHEMBL1482541 | 0.82 | CHRM1 (0.54) | CHRM1LMNAKDM4ETSHR | |
| SCHEMBL3234394 | 0.81 | CHRM1 (0.86) | CHRM1LMNAMAPTTP53 | |
| SCHEMBL3230348 | 0.80 | CHRM1 (0.72) | CHRM1LMNAMAPT | |
| SCHEMBL1482024 | 0.80 | CHRM1 (0.59) | CHRM1LMNAMAPTKDM4ETSHR | |
| SCHEMBL2485615 | 0.79 | CHRM1 (0.77) | CHRM1LMNA | |
| SCHEMBL1481671 | 0.78 | CHRM1 (0.62) | CHRM1LMNAMAPTKDM4ETSHR | |
| SCHEMBL14747460 | 0.78 | CHRM1 (0.72) | CHRM1LMNAMAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8293914-B2 | 4-OXO,1-4-dihydroquinoline M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293914-B2 | 4-OXO,1-4-dihydroquinoline M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-8293914-B2 | 4-OXO,1-4-dihydroquinoline M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2012-10-23 | — | — | US | disclosed |
| US-20110077220-A1 | 4-OXO,1-4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-31 | — | — | US | disclosed |
| US-20110077220-A1 | 4-OXO,1-4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-31 | — | — | US | disclosed |
| US-20110077220-A1 | 4-OXO,1-4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME CORP. | 2011-03-31 | — | — | US | disclosed |
| WO-2009134668-A2 | 4-OXO-1,4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK & CO., INC. (US) | 2009-11-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110077220-A1 | 4-OXO,1-4-DIHYDROQUINOLINE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRM1, OPRL1 | CHRM1 1/4885LMNA 4479/4885MAPT 585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.