SCHEMBL1482895

SCHEMBL1482895

ONc1ccc[nH]1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3194321 0.77 DAO (0.35)
SCHEMBL1566543 0.74
SCHEMBL5136344 0.72
SCHEMBL85297 0.72
SCHEMBL9918670 0.72
SCHEMBL9402161 0.72
SCHEMBL10506831 0.72 HDAC1 (0.41)
SCHEMBL11741569 0.72
SCHEMBL1042017 0.72
SCHEMBL29994134 0.72 RAB9A (0.39)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 62 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115300640-A Novel linkers and their use for specific coupling of drugs and biomolecules 杭州多禧生物科技有限公司 2022-11-08 CN claimed
US-20180140722-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF HEART FAILURE NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-05-24 US claimed
US-20170105952-A1 HISTONE ACETYL TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2017-04-20 US claimed
WO-2016164482-A1 METHODS AND COMPOSITIONS FOR TREATMENT OF HEART FAILURE THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2016-10-13 WO claimed
US-20150246010-A1 HISTONE ACETYL TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2015-09-03 US claimed
US-20100144885-A1 HISTONE ACETYL TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2010-06-10 US claimed
EP-2073812-A2 HISTONE ACETYLE TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM The Board of Trustees of the University of Illinois (US) 2009-07-01 EP claimed
EP-2040731-A2 SOLID ORAL DOSAGE FORM CONTAINING AN ENHANCER Merrion Research III Limited (IE) 2009-04-01 EP claimed
WO-2008042795-A2 HISTONE ACETYLE TRANSFERASE ACTIVATORS AND HISTONE DEACETYLASE INHIBITORS IN THE TREATMENT OF ALCOHOLISM THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) 2008-04-10 WO claimed
WO-2007146234-A2 SOLID ORAL DOSAGE FORM CONTAINING AN ENHANCER MERRION RESEARCH II LIMITED (IE) 2007-12-21 WO claimed
US-20070292512-A1 Solid Oral Dosage Form Containing an Enhancer MERRION RESEARCH II LIMITED (IE) 2007-12-20 US claimed
US-20070148228-A1 Solid oral dosage form containing an enhancer MERRION RESEARCH I LIMITED (IE) 2007-06-28 US claimed
CN-117866042-A Disulfide-containing cell penetrating peptides and methods of making and using the same 俄亥俄州国家创新基金会 2024-04-12 CN disclosed
US-11938105-B1 Methods and compositions for the treatment of cancer cachexia OHIO STATE INNOVATION FOUNDATION (US) 2024-03-26 US disclosed
CN-110114075-B Disulfide-containing cell penetrating peptides and methods of making and using the same 俄亥俄州国家创新基金会 2024-01-12 CN disclosed
CN-116785293-A Compounds and methods for treating infections 尼奥酷里私人有限公司 2023-09-22 CN disclosed
US-20070148228-A1 Solid oral dosage form containing an enhancer MERRION RESEARCH I LIMITED (IE) 2007-06-28 US disclosed
EP-1745032-A2 CXCR1 AND CXCR2 CHEMOKINE ANTAGONISTS Schering Cooperation (US) 2007-01-24 EP disclosed
US-20060014794-A1 CXCR1 and CXCR2 chemokine antagonists SCHERING CORPORATION 2006-01-19 US disclosed
WO-2005113534-A2 CXCR1 AND CXCR2 CHEMOKINE ANTAGONISTS SCHERING CORPORATION (US) 2005-12-01 WO disclosed