SCHEMBL14829136

SCHEMBL14829136

Cc1ccccc1N1CCN(S(=O)(=O)C[C@]23CC[C@H](CC2NC(=O)[C@@H](N)CCS(C)(=O)=O)C3(C)C)CC1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
OXTR P30559 5/20 1.00
AVPR2 P30518 2/20 1.00
AVPR1A P37288 2/20 1.00
CYP3A4 P08684 1/20 1.00
TSHR P16473 1/20 1.00
MEN1 O00255 1/20 0.98
BLM P54132 1/20 0.98
PMP22 Q01453 1/20 0.98
KMT2A Q03164 1/20 0.98
OPRK1 P41145 1/20 0.98
TMEM97 Q5BJF2 1/20 0.98
SIGMAR1 Q99720 1/20 0.98
AVPR1B P47901 1/20 0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7278360 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL12636892 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL26813473 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL29766904 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL17423276 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL7303364 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL17423280 1.00 OXTR (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
Hydrochloric Acid SCHEMBL30515732 0.99 MEN1 (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
Hydrochloric Acid SCHEMBL29371071 0.99 MEN1 (1.00) OXTRAVPR2AVPR1ACYP3A4TSHR
SCHEMBL7305556 0.93 OXTR (0.87) OXTRAVPR2AVPR1ACYP3A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140235556-A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS BIOMED VALLEY DISCOVERIES, INC. 2014-08-21 US claimed
EP-2760473-A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS Biomed Valley Discoveries, Inc. (US) 2014-08-06 EP claimed
CN-103930132-A Compositions and methods of treating gliomas BIOMED VALLEY DISCOVERIES INC 2014-07-16 CN claimed
WO-2013049045-A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS BIOMED VALLEY DISCOVERIES, INC. (US) 2013-04-04 WO claimed
US-11752157-B2 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies FERRING B.V. (NL) 2023-09-12 US disclosed
CN-113940990-A Oxytocin receptor antagonists 辉凌有限公司 2022-01-18 CN disclosed
CN-107249618-B Oxytocin receptor antagonist treatment in the luteal phase of implantation and pregnancy in women undergoing assisted reproductive technologies 辉凌有限公司 2021-11-16 CN disclosed
US-20200352962-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES FERRING B.V. (NL) 2020-11-12 US disclosed
US-10688106-B2 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies FERRING B.V. (NL) 2020-06-23 US disclosed
EP-3501533-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES Ferring B.V. (NL) 2019-06-26 EP disclosed
US-10183029-B2 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies FERRING B.V. (NL) 2019-01-22 US disclosed
US-20170348325-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES FERRING B.V. (NL) 2017-12-07 US disclosed
WO-2016105190-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES FERRING B.V. (NL) 2016-06-30 WO disclosed
EP-3037101-A1 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies Ferring B.V. (NL) 2016-06-29 EP disclosed
US-20160175283-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES FERRING B.V. (NL) 2016-06-23 US disclosed
WO-2016007421-A1 METHODS AND COMPOSITIONS FOR MODULATING LUNG CANCER TUMOR INITIATING CELLS (TIC), AND OXYTOCIN RECEPTOR (OXTR) MODULATORY AGENTS FOR USE IN PRACTICING THE SAME THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) 2016-01-14 WO disclosed
US-20140235556-A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS BIOMED VALLEY DISCOVERIES, INC. 2014-08-21 US disclosed
EP-2760473-A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS Biomed Valley Discoveries, Inc. (US) 2014-08-06 EP disclosed
CN-103930132-A Compositions and methods of treating gliomas BIOMED VALLEY DISCOVERIES INC 2014-07-16 CN disclosed
WO-2013049045-A1 COMPOSITIONS AND METHODS OF TREATING GLIOMAS BIOMED VALLEY DISCOVERIES, INC. (US) 2013-04-04 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20200352962-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES OXTR, GNRHR, LHCGR OXTR 1/4885AVPR2 8/4885AVPR1A 7/4885
US-20160175283-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES OXTR, GNRHR, LHCGR OXTR 1/4885AVPR2 8/4885AVPR1A 7/4885
US-20170348325-A1 OXYTOCIN RECEPTOR ANTAGONIST THERAPY IN THE LUTEAL PHASE FOR IMPLANTATION AND PREGNANCY IN WOMEN UNDERGOING ASSISTED REPRODUCTIVE TECHNOLOGIES OXTR, GNRHR, LHCGR OXTR 1/4885AVPR2 8/4885AVPR1A 7/4885
US-10183029-B2 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies OXTR, GNRHR, LHCGR OXTR 1/4885AVPR2 8/4885AVPR1A 7/4885
US-10688106-B2 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies OXTR, GNRHR, LHCGR OXTR 1/4885AVPR2 8/4885AVPR1A 7/4885
US-11752157-B2 Oxytocin receptor antagonist therapy in the luteal phase for implantation and pregnancy in women undergoing assisted reproductive technologies OXTR, GNRHR, LHCGR OXTR 1/4885AVPR2 8/4885AVPR1A 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.