Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.47 |
| ▸ | CYP4F2 | P78329 | 2/20 | 0.46 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4258353 | 0.87 | ALDH1A1 (0.49) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL1926585 | 0.87 | TSHR (0.60) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL16720308 | 0.85 | KDM4E (0.55) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL10411912 | 0.85 | ALDH1A1 (0.52) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL4672150 | 0.83 | ALDH1A1 (0.51) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL13780436 | 0.81 | CA12 (0.48) | ALDH1A1TSHRCYP1A2CYP2C9MAPT | |
| SCHEMBL14829600 | 0.81 | ALDH1A1 (0.45) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL27914434 | 0.80 | PTPN11 (0.59) | ALDH1A1TSHRRAB9ALOXL2CYP1A2 | |
| SCHEMBL1800821 | 0.80 | TSHR (0.53) | ALDH1A1CYP3A4MAPK1TSHRRAB9A | |
| SCHEMBL18401454 | 0.79 | POLB (0.51) | ALDH1A1CYP3A4MAPK1TSHRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103254236-A | Preparation method of 4-aryl coumarin-3-phosphonate derivatives | UNIV SOOCHOW | 2013-08-21 | — | — | CN | claimed |
| US-10766872-B2 | Compounds for the treatment of mycobacterial infections | THE BOARD INSTITUTE, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766872-B2 | Compounds for the treatment of mycobacterial infections | THE BOARD INSTITUTE, INC. (US) | 2020-09-08 | — | — | US | disclosed |
| US-RE48105-E1 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-RE48105-E1 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2020-07-21 | — | — | US | disclosed |
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-11-16 | — | — | US | disclosed |
| US-9682064-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-9682064-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2017-06-20 | — | — | US | disclosed |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-01-19 | — | — | US | disclosed |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | BROAD INST INC (US) | 2017-01-19 | — | — | US | disclosed |
| US-9416121-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416121-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-9416121-B2 | Compounds for the treatment of mycobacterial infections | THE BROAD INSTITUTE, INC. (US) | 2016-08-16 | — | — | US | disclosed |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | MASSACHUSETTS GENERAL HOSPITAL (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | MASSACHUSETTS GENERAL HOSPITAL (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | MASSACHUSETTS GENERAL HOSPITAL (US) | 2014-10-02 | — | — | US | disclosed |
| CN-103254236-A | Preparation method of 4-aryl coumarin-3-phosphonate derivatives | UNIV SOOCHOW | 2013-08-21 | — | — | CN | disclosed |
| WO-2013049567-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | THE BROAD INSTITUTE, INC. (US) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170327481-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GBA1, ASAH2, MPI | ALDH1A1 759/4885CYP3A4 748/4885MAPK1 1355/4885 |
| US-20170014378-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GBA1, ASAH2, MPI | ALDH1A1 759/4885CYP3A4 748/4885MAPK1 1355/4885 |
| US-20140296232-A1 | COMPOUNDS FOR THE TREATMENT OF MYCOBACTERIAL INFECTIONS | GBA1, ASAH2, MPI | ALDH1A1 759/4885CYP3A4 748/4885MAPK1 1355/4885 |
| US-10766872-B2 | Compounds for the treatment of mycobacterial infections | GBA1, ASAH2, MPI | ALDH1A1 759/4885CYP3A4 748/4885MAPK1 1355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.