Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 4/20 | 0.36 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.36 |
| ▸ | MINK1 | Q8N4C8 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.36 |
| ▸ | SRPK1 | Q96SB4 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.36 |
| ▸ | CLK2 | P49760 | 3/20 | 0.36 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.36 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.36 |
| ▸ | GSK3B | P49841 | 2/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.36 |
| ▸ | RHOA | P61586 | 1/20 | 0.36 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12199223 | 0.76 | KDM4E (1.00) | KDM4EALDH1A1POLBGAAMAP4K4 | |
| SCHEMBL3299277 | 0.76 | ALDH1A1 (0.44) | KDM4EALDH1A1POLBGAAMAP4K4 | |
| SCHEMBL14829606 | 0.73 | MEN1 (0.39) | KDM4EALDH1A1PIK3CARHOACYP1A2 | |
| SCHEMBL15652730 | 0.72 | KDM4E (0.42) | KDM4EALDH1A1POLBLMNA | |
| SCHEMBL14829741 | 0.69 | TGFBR1 (0.42) | KDM4EALDH1A1POLBCDK1CDK5 | |
| SCHEMBL5909656 | 0.69 | ALDH1A1 (0.47) | KDM4EALDH1A1POLBGAADYRK1A | |
| SCHEMBL16507518 | 0.69 | CDK8 (0.47) | KDM4EALDH1A1POLBGAAEGFR | |
| SCHEMBL14829842 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1POLBGAAPIK3CA | |
| SCHEMBL14829742 | 0.68 | KDM4E (0.47) | KDM4EALDH1A1POLBGAAPIK3CA | |
| SCHEMBL13365646 | 0.68 | KDM4E (0.61) | KDM4EALDH1A1POLBGAAMAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013049701-A1 | CERTAIN CHEMICAL ENTITIES, COMPOSITIONS, AND METHODS | NEUPHARMA, INC. (US) | 2013-04-04 | — | — | WO | claimed |
| US-20170050938-A1 | SUBSTITUTED QUINOXALINES AS B-RAF KINASE INHIBITORS | NEUPHARMA, INC. | 2017-02-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170050938-A1 | SUBSTITUTED QUINOXALINES AS B-RAF KINASE INHIBITORS | BRAF, RAF1, ARAF | KDM4E 1448/4885ALDH1A1 2511/4885POLB 1144/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.