Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPSR1 | Q6W5P4 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | XBP1 | P17861 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.44 |
| ▸ | SCN9A | Q15858 | 3/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MIF | P14174 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | BCL2 | P10415 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975053 | 0.88 | NPSR1 (0.56) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL2065478 | 0.79 | MEN1 (0.50) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL8225124 | 0.74 | EPHX2 (0.47) | SMN1; SMN2MEN1KMT2ASCN5ASCN9A | |
| SCHEMBL26930231 | 0.72 | NPSR1 (0.43) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL26930210 | 0.71 | NPSR1 (0.42) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL30606439 | 0.70 | KIF11 (0.49) | NPSR1SMN1; SMN2HTTL3MBTL1MAPK1 | |
| SCHEMBL11618396 | 0.70 | KIF11 (0.49) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL10862316 | 0.68 | NPSR1 (0.54) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL26930303 | 0.68 | NPSR1 (0.51) | NPSR1SMN1; SMN2HTTL3MBTL1MEN1 | |
| SCHEMBL3172531 | 0.68 | CYP2C9 (0.47) | NPSR1HTTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760845-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013049250-A1 | HETEROCYCLIC COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2013-04-04 | — | — | WO | disclosed |