Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IRAK4 | Q9NWZ3 | 4/20 | 0.39 |
| ▸ | HPGDS | O60760 | 2/20 | 0.38 |
| ▸ | PDE5A | O76074 | 4/20 | 0.38 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.38 |
| ▸ | CCNC | P24863 | 2/20 | 0.37 |
| ▸ | CDK8 | P49336 | 2/20 | 0.37 |
| ▸ | CDKN1A | P38936 | 1/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.36 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.36 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.35 |
| ▸ | MAP3K14 | Q99558 | 1/20 | 0.35 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | KDR | P35968 | 1/20 | 0.35 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16936961 | 0.80 | CA1 (0.41) | HPGDSPDE5ACHUKMAP3K14KCNH2 | |
| SCHEMBL6812511 | 0.74 | IMPDH2 (0.43) | GSK3B | |
| SCHEMBL1727666 | 0.73 | KDM4E (0.52) | — | |
| SCHEMBL27761499 | 0.73 | IMPDH2 (0.42) | GSK3B | |
| SCHEMBL30951595 | 0.73 | KDM4E (0.52) | — | |
| SCHEMBL14324136 | 0.72 | PDE5A (0.37) | PDE5ACHUK | |
| SCHEMBL6536105 | 0.72 | KDM4E (0.56) | IRAK4CCNCCDK8CDKN1ACDK19 | |
| SCHEMBL30481668 | 0.72 | MAPK10 (0.39) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL14830830 | 0.72 | MAPK10 (0.39) | IRAK4MAP4K4CCNCCDK8CDKN1A | |
| SCHEMBL31189278 | 0.71 | IMPDH2 (0.39) | HPGDSGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2760841-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045400-A1 | PYRAZOLOQUINOLINONE DERIVATIVES, PREPARATION THEREOF AND THERAPEUTIC USE THEREOF | SANOFI (FR) | 2013-04-04 | — | — | WO | disclosed |