Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | GAA | P10253 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 5/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | GAK | O14976 | 1/20 | 0.36 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.35 |
| ▸ | IMPDH1 | P20839 | 1/20 | 0.35 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL14833948 | 0.98 | GAA (0.46) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL19696314 | 0.94 | MAPT (0.42) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL7891011 | 0.87 | CYP19A1 (0.44) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL14320992 | 0.85 | MAPT (0.46) | MAPTGAATSHRMAPK1HTT | |
| Hydrochloric Acid SCHEMBL7464368 | 0.82 | GAA (0.46) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL8419857 | 0.81 | CA12 (0.47) | MAPTGAAALDH1A1LMNA | |
| SCHEMBL6571978 | 0.81 | HTR7 (0.41) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL6572269 | 0.81 | NR3C1 (0.39) | MAPTGAATSHRMAPK1HTT | |
| SCHEMBL6081370 | 0.81 | GAA (0.52) | MAPTGAATSHRMAPK1HTT | |
| Hydrochloric Acid SCHEMBL9793009 | 0.80 | CA12 (0.46) | MAPTGAAALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9840729-B2 | Azo mediators and methods of use thereof | ROCHE DIABETES CARE, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| EP-2760825-B1 | AZO MEDIATORS | HOFFMANN LA ROCHE (CH) | 2016-09-14 | — | — | EP | disclosed |
| EP-2760825-A1 | AZO MEDIATORS | F.HOFFMANN-LA ROCHE AG (CH) | 2014-08-06 | — | — | EP | disclosed |
| US-20140212903-A1 | AZO MEDIATORS AND METHODS OF USE THEREOF | ROCHE DIAGNOSTICS OPERATIONS, INC. (US) | 2014-07-31 | — | — | US | disclosed |
| WO-2013045487-A1 | AZO MEDIATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-04 | — | — | WO | disclosed |
| WO-2013045487-A1 | AZO MEDIATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2013-04-04 | — | — | WO | disclosed |