Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1483338 | 0.99 | — | — | |
| SCHEMBL4267254 | 0.88 | — | — | |
| SCHEMBL1483678 | 0.81 | KDM4E (0.38) | — | |
| SCHEMBL1483304 | 0.80 | — | — | |
| Bromide SCHEMBL4265292 | 0.78 | ALOX5AP (0.40) | — | |
| SCHEMBL1483655 | 0.78 | — | — | |
| Bromide SCHEMBL4471147 | 0.77 | HSD11B1 (0.39) | — | |
| SCHEMBL1483251 | 0.77 | ALOX5AP (0.41) | — | |
| Bromide SCHEMBL4472191 | 0.77 | CYP11B1 (0.37) | — | |
| Bromide SCHEMBL4477940 | 0.76 | ALOX5AP (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8541440-B2 | Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics | SANOFI (FR) | 2013-09-24 | — | — | US | disclosed |
| US-20110077264-A1 | DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS | SANOFI-AVENTIS (FR) | 2011-03-31 | — | — | US | disclosed |
| US-7863290-B2 | Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics | SANOFI-AVENTIS (FR) | 2011-01-04 | — | — | US | disclosed |