Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | KCNA5 | P22460 | 6/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.38 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.38 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17064526 | 0.88 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL17061221 | 0.80 | FFAR1 (0.55) | SLC6A2SLC6A4SLC6A3KCNA5FFAR2 | |
| SCHEMBL28786232 | 0.77 | SLC6A2 (0.39) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL21742088 | 0.76 | TP53 (0.53) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL23970339 | 0.75 | SLC6A2 (0.47) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL8599511 | 0.75 | KCNA5 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL22961730 | 0.75 | KCNA5 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL6370490 | 0.75 | KCNA5 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL8598551 | 0.75 | KCNA5 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 | |
| SCHEMBL8004235 | 0.75 | KCNA5 (0.44) | SLC6A2SLC6A4SLC6A3KCNA5KCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2576510-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2013-04-10 | — | — | EP | disclosed |
| WO-2011153509-A1 | PIPERIDINONE DERIVATIVES AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2011-12-08 | — | — | WO | disclosed |