Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.32 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.32 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL145684 | 0.81 | JAK2 (0.38) | JAK2BTKKCNN4P2RX7 | |
| SCHEMBL3689991 | 0.78 | ALDH1A1 (0.31) | JAK2BTK | |
| SCHEMBL148300 | 0.77 | P2RX7 (0.38) | JAK2BTKNOTUMP2RX7 | |
| SCHEMBL148801 | 0.77 | P2RX7 (0.38) | JAK2BTKP2RX7 | |
| SCHEMBL145048 | 0.74 | MEN1 (0.31) | — | |
| SCHEMBL145352 | 0.74 | ALDH1A1 (0.31) | — | |
| SCHEMBL144266 | 0.71 | TIPARP (0.45) | JAK2BTKNOTUMP2RX7 | |
| SCHEMBL146675 | 0.70 | JAK2 (0.38) | JAK2BTKNOTUMKCNN4P2RX7 | |
| SCHEMBL148364 | 0.67 | JAK2 (0.39) | JAK2BTKKCNN4P2RX7 | |
| SCHEMBL741586 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8362065-B2 | Carbazole carboxamide compounds useful as kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-01-29 | — | — | US | disclosed |
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BRISTOL-MYERS SQUIBB COMPANY | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058996-A1 | CARBAZOLE CARBOXAMIDE COMPOUNDS USEFUL AS KINASE INHIBITORS | BTK, FLT3, JAK1 | JAK2 13/4885BTK 1/4885NOTUM 1923/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.