SCHEMBL14837362

SCHEMBL14837362

O=C(O)O[C@@H]1Cc2ccccc2CN1S(=O)(=O)c1ccc(-c2ccc([N+](=O)[O-])cc2)cc1

nearest known ligand 0.54

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MMP8 P22894 20/20 0.54
MMP3 P08254 12/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6889052 0.84 MMP8 (0.66) MMP8MMP3
SCHEMBL6889057 0.84 MMP8 (0.66) MMP8MMP3
SCHEMBL6010486 0.81 MMP8 (0.68) MMP8MMP3
SCHEMBL6885390 0.80 MMP8 (0.59) MMP8MMP3
SCHEMBL31685897 0.80 POLB (0.69) MMP8MMP3
SCHEMBL26616325 0.80 POLB (0.69) MMP8MMP3
SCHEMBL5960179 0.80 POLB (0.69) MMP8MMP3
SCHEMBL26616335 0.80 POLB (0.69) MMP8MMP3
SCHEMBL7299752 0.78 MCL1 (0.55) MMP8MMP3
SCHEMBL6685185 0.77 MMP8 (0.53) MMP8MMP3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1483244-B1 CYCLIC N-SUBSTITUTED ALPHA IMINOCARBOXYLIC ACIDS FOR SELECTIVELY INHIBITING COLLAGENASE SANOFI AVENTIS DEUTSCHLAND (DE) 2013-04-10 EP disclosed