Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | MMP8 | P22894 | 13/20 | 0.49 |
| ▸ | MMP3 | P08254 | 7/20 | 0.49 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6010486 | 0.85 | MMP8 (0.68) | MMP8MMP3POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL8576251 | 0.82 | POLB (0.67) | MCL1KDM4EALDH1A1MMP8MMP3 | |
| SCHEMBL7299750 | 0.82 | POLB (0.67) | MCL1KDM4EALDH1A1MMP8MMP3 | |
| SCHEMBL7329088 | 0.79 | AKR1C3 (0.56) | KDM4EALDH1A1AKR1C3AKR1C1 | |
| SCHEMBL14837362 | 0.78 | MMP8 (0.54) | MMP8MMP3 | |
| SCHEMBL2568805 | 0.77 | ALDH1A1 (0.47) | MCL1KDM4EALDH1A1MMP8MMP3 | |
| SCHEMBL6010325 | 0.74 | MMP8 (0.67) | MMP8MMP3POLBAPOBEC3AAPOBEC3G | |
| SCHEMBL6010136 | 0.73 | MMP8 (0.47) | MMP8MMP3POLB | |
| SCHEMBL1024395 | 0.73 | MMP8 (0.50) | MMP8MMP3 | |
| SCHEMBL8304904 | 0.71 | AKR1C3 (0.64) | KDM4EALDH1A1AKR1C3TDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468231-B1 | Guanidins | HOFFMANN LA ROCHE (CH) | 1994-09-21 | — | — | EP | disclosed |
| EP-0468231-A2 | Guanidins | F. HOFFMANN-LA ROCHE AG (CH) | 1992-01-29 | — | — | EP | disclosed |