Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR2 | Q8NFJ6 | 4/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.37 |
| ▸ | DRD4 | P21917 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | RXRB | P28702 | 1/20 | 0.36 |
| ▸ | GPR6 | P46095 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837329 | 0.92 | PROKR2 (0.50) | PROKR2LMNAPKMDRD4KMT2A | |
| SCHEMBL14837318 | 0.90 | PROKR2 (0.51) | PROKR2LMNAPKMKMT2AMEN1 | |
| SCHEMBL14837397 | 0.89 | PROKR2 (0.49) | PROKR2LMNAPKMDRD4KMT2A | |
| SCHEMBL14837236 | 0.88 | PROKR2 (0.53) | PROKR2LMNAPKMDRD4KMT2A | |
| SCHEMBL14837345 | 0.88 | PROKR2 (0.63) | PROKR2LMNAPKMDRD4KMT2A | |
| SCHEMBL14837357 | 0.88 | PROKR2 (0.51) | PROKR2LMNAPKMDRD4KMT2A | |
| SCHEMBL14837341 | 0.88 | PROKR2 (0.48) | PROKR2LMNAPKMKMT2AALDH1A1 | |
| SCHEMBL14837261 | 0.87 | PROKR2 (0.50) | PROKR2LMNAPKMKMT2AALDH1A1 | |
| SCHEMBL3521149 | 0.87 | PROKR2 (0.51) | PROKR2MTNR1BPPARGDRD4KMT2A | |
| SCHEMBL14837278 | 0.87 | PROKR2 (0.48) | PROKR2LMNAPKMDRD4RXRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959959-B1 | MORPHOLINE CARBOXAMIDE PROKINETICIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-04-10 | — | — | EP | claimed |