Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PROKR2 | Q8NFJ6 | 4/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | FAAH | O00519 | 1/20 | 0.37 |
| ▸ | TACR1 | P25103 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14837353 | 0.93 | PROKR2 (0.49) | PROKR2KDM4EDRD4LMNAPKM | |
| SCHEMBL14837429 | 0.90 | PROKR2 (0.53) | PROKR2ALDH1A1KDM4EDRD4LMNA | |
| SCHEMBL14837329 | 0.90 | PROKR2 (0.50) | PROKR2ALDH1A1KDM4EDRD4LMNA | |
| SCHEMBL14837449 | 0.90 | PROKR2 (0.54) | PROKR2DRD4LMNAPKMGRIN2B | |
| SCHEMBL14837384 | 0.89 | PROKR2 (0.54) | PROKR2ALDH1A1KDM4EGAADRD4 | |
| SCHEMBL14837261 | 0.89 | PROKR2 (0.50) | PROKR2ALDH1A1KDM4ELMNAPKM | |
| SCHEMBL14837372 | 0.89 | PROKR2 (0.48) | PROKR2ALDH1A1KDM4EDRD4LMNA | |
| SCHEMBL14837345 | 0.88 | PROKR2 (0.63) | PROKR2DRD4LMNAPKMGRIN2B | |
| SCHEMBL14837428 | 0.88 | PROKR2 (0.51) | PROKR2ALDH1A1KDM4EDRD4LMNA | |
| SCHEMBL3520404 | 0.87 | PROKR2 (0.49) | PROKR2ALDH1A1KDM4EGAADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1959959-B1 | MORPHOLINE CARBOXAMIDE PROKINETICIN RECEPTOR ANTAGONISTS | MERCK SHARP & DOHME (US) | 2013-04-10 | — | — | EP | claimed |