Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.40 |
| ▸ | PARP1 | P09874 | 7/20 | 0.37 |
| ▸ | DPP7 | Q9UHL4 | 2/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.33 |
| ▸ | PIM1 | P11309 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL917830 | 0.83 | PARP1 (0.37) | PARP1FTOALDH1A1POLBKMT2A | |
| SCHEMBL14837200 | 0.83 | PARP1 (0.43) | PARP1ALDH1A1KMT2AKDM4EMEN1 | |
| SCHEMBL917909 | 0.83 | PARP1 (0.39) | PARP1HTR6 | |
| SCHEMBL14837095 | 0.82 | PARP1 (0.39) | PARP1FTOALDH1A1POLBKDM4E | |
| SCHEMBL917641 | 0.82 | PARP1 (0.38) | PARP1ALDH1A1HTR6 | |
| SCHEMBL918647 | 0.80 | FTO (0.36) | PARP1FTOPOLBALKBH5 | |
| SCHEMBL14837181 | 0.79 | LDHA (0.42) | PARP1DPP7FTOALDH1A1HTR6 | |
| SCHEMBL918232 | 0.78 | PARP1 (0.35) | PARP1FTOALDH1A1KMT2AMEN1 | |
| SCHEMBL14836947 | 0.77 | PARP1 (0.39) | PARP1KMT2A | |
| SCHEMBL14837119 | 0.77 | PARP1 (0.38) | PARP1FTOALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1758864-B1 | Substituted tetrahydro-2H-isoquinolin-1-one derivatives, method for their preparation, and their use as medicaments | SANOFI AVENTIS DEUTSCHLAND (DE) | 2013-04-10 | — | — | EP | disclosed |