Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.32 |
| ▸ | GABRP | O00591 | 1/20 | 0.32 |
| ▸ | GABRD | O14764 | 1/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL10953798 | 1.00 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28175000 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28020653 | 0.96 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Phosphonic Acid SCHEMBL5482535 | 0.96 | — | — | |
| Piperazine SCHEMBL28020651 | 0.93 | HIF1A (0.43) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28534942 | 0.87 | HIF1A (0.38) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28545949 | 0.87 | LMNA (0.42) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Pyrrolidine SCHEMBL11618713 | 0.85 | ALDH1A1 (0.53) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28020257 | 0.84 | FFAR3 (0.41) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Azepane SCHEMBL1450973 | 0.82 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-114805652-A | Flame-retardant PMMA resin material, composite material and preparation method thereof | 北玻院(滕州)复合材料有限公司 | 2022-07-29 | — | — | CN | claimed |
| CN-109942824-B | Nitrogen-containing phosphonate flame retardant and synthetic method thereof | 黑龙江科技大学 | 2021-07-09 | — | — | CN | claimed |
| US-20080029126-A1 | Compositions and methods for improved planarization of copper utilizing inorganic oxide abrasive | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2008-02-07 | — | — | US | claimed |
| US-6971945-B2 | Multi-step polishing solution for chemical mechanical planarization | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. (US) | 2005-12-06 | — | — | US | claimed |
| US-20050194357-A1 | MULTI-STEP POLISHING SOLUTION FOR CHEMICAL MECHANICAL PLANARIZATION | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-09-08 | — | — | US | claimed |
| EP-1548076-A1 | Compositions and methods for low downforce pressure polishing of copper | Rohm and Haas Electronic Materials CMP Holdings, Inc. (US) | 2005-06-29 | — | — | EP | claimed |
| US-20050136671-A1 | Compositions and methods for low downforce pressure polishing of copper | ROHM AND HAAS ELECTRONIC MATERIALS CMP HOLDINGS, INC. | 2005-06-23 | — | — | US | claimed |
| US-4540508-A | PIPERAZINE DERIVATIVES | THE DOW CHEMICAL COMPANY (US) | 1985-09-10 | — | — | US | claimed |
| US-3954761-A | SCALE AND CORROSION INHIBITORS | PETROLITE CORPORATION (US) | 1976-05-04 | — | — | US | claimed |
| CN-114805652-B | Flame-retardant PMMA resin material, composite material and preparation method thereof | 北玻院(滕州)复合材料有限公司 | 2023-10-13 | — | — | CN | disclosed |
| CN-115975296-A | Halogen-free flame-retardant polyolefin composition and preparation method thereof | 北京航天凯恩新材料有限公司 | 2023-04-18 | — | — | CN | disclosed |
| CN-115819453-A | Phosphorus-containing epoxy curing agent and preparation method thereof | 河南昇阳生物科技有限公司 | 2023-03-21 | — | — | CN | disclosed |
| CN-114805652-A | Flame-retardant PMMA resin material, composite material and preparation method thereof | 北玻院(滕州)复合材料有限公司 | 2022-07-29 | — | — | CN | disclosed |
| CN-109942824-B | Nitrogen-containing phosphonate flame retardant and synthetic method thereof | 黑龙江科技大学 | 2021-07-09 | — | — | CN | disclosed |
| US-5500419-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1996-03-19 | — | — | US | disclosed |
| EP-0418863-B1 | NMDA antagonists | MERRELL DOW PHARMA (US) | 1995-01-04 | — | — | EP | disclosed |
| US-5326756-A | R-4-oxo-5 phosphononorvaline used as NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-07-05 | — | — | US | disclosed |
| US-5095009-A | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0418863-A2 | NMDA antagonists | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-03-27 | — | — | EP | disclosed |
| US-3954761-A | SCALE AND CORROSION INHIBITORS | PETROLITE CORPORATION (US) | 1976-05-04 | — | — | US | disclosed |