Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8021640 | 0.80 | — | — | |
| Potassium Ion SCHEMBL5961719 | 0.80 | — | — | |
| Choline SCHEMBL17598957 | 0.80 | SMN1; SMN2 (0.48) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| SCHEMBL4581599 | 0.73 | SLC22A1 (0.41) | LMNACYP3A4SMN1; SMN2 | |
| Choline SCHEMBL136983 | 0.72 | MEN1 (0.63) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL1934637 | 0.70 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9447024 | 0.70 | MEN1 (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL9447076 | 0.70 | MEN1 (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL15922003 | 0.70 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 | |
| Choline SCHEMBL136984 | 0.70 | LMNA (0.60) | MEN1LMNAKMT2ACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130089912-A1 | METHODS AND COMPOSITIONS FOR THE STABILIZATION OF BIOLOGIC MATERIAL | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE | 2013-04-11 | — | — | US | disclosed |