Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3GNRHRMPLPDE3APDE3BPDE4APDE4BPDE4CPDE4DPPARASLC5A2
The experimentally established mechanism targets of Choline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 known ✓ | P0DMS8 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 5/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.63 |
| ▸ | LMNA | P02545 | 3/20 | 0.63 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.63 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.63 |
| ▸ | BBOX1 | O75936 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | ESR1 | P03372 | 1/20 | 0.39 |
| ▸ | CDC25A | P30304 | 1/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.39 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 3/20 | 0.39 |
| ▸ | APEX1 | P27695 | 3/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Choline SCHEMBL9447024 | 0.97 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9447035 | 0.97 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL28375564 | 0.97 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL9447076 | 0.97 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL316335 | 0.97 | MEN1 (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL7782023 | 0.97 | CYP3A4 (0.68) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL7646161 | 0.95 | MEN1 (0.57) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL14856340 | 0.95 | CYP3A4 (0.65) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL1934637 | 0.92 | LMNA (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 | |
| Choline SCHEMBL15922003 | 0.92 | LMNA (0.60) | MEN1KMT2ALMNACYP3A4SLC5A7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1948 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12635684-B2 | Methods and compositions for biopreservation | THE UNIVERSITY OF NORTH CAROLINA AT CHARLOTTE (US) | 2026-05-26 | — | — | US | claimed |
| CN-122060130-A | Choline phosphate modified quantum dot composite material and preparation method and application thereof | 中国石油化工股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| CN-122036023-A | Marine antifouling and antibacterial structure with adjustable release period and preparation process thereof | 居峥 | 2026-05-15 | — | — | CN | claimed |
| CN-122017227-A | Choline phosphate modified magnetic ball and preparation method and application thereof | 中国石油化工股份有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12551441-B2 | Water soluble silicon-containing granulate | BIO MINERALS NV (BE) | 2026-02-17 | — | — | US | claimed |
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | ENTEGRIS INC (US) | 2026-01-15 | — | — | US | claimed |
| US-20260000766-A1 | ULTRASOUND OPTOGENETIC COMPOSITIONS AND METHODS | UNIV TEXAS (US) | 2026-01-01 | — | — | US | claimed |
| US-20250302343-A1 | AN ELECTRODE ARRAY FOR MEASURING THE PH OF ANIMAL TISSUES, A PROBE COMPRISING SUCH AN ARRAY, AND AN ASSEMBLY COMPRISING SAID PROBE | QUANTUM INNOVATIONS SP. Z O.O. (PL) | 2025-10-02 | — | — | US | claimed |
| US-20250213749-A1 | METHOD FOR PREPARING BIOLOGICAL VALVE MATERIAL BY COPOLYMERIZATION AND CROSSLINKING, BIOLOGICAL VALVE MATERIAL AND USE | SICHUAN UNIVERSITY (CN) | 2025-07-03 | — | — | US | claimed |
| WO-2025101765-A9 | NOVEL LIVER-TARGETING GLUCOCORTICOID PRODRUGS | THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK (US) | 2025-06-19 | — | — | WO | claimed |
| US-5215973-A | Treating anhydrous form with water; crystallization from organic solvent of medium polarity; antilipemic agents | MAGIS FARMACEUTICI S.P.A. (IT) | 1993-06-01 | — | — | US | claimed |
| EP-0502357-A1 | Optically active and racemic hydrated diacetylesters of alpha-glycero-phosphoryl-choline | MAGIS FARMACEUTICI S.p.A. (IT) | 1992-09-09 | — | — | EP | claimed |
| WO-1990012565-A1 | WATER-CONTAINING FORMULATIONS WITH PHOSPHOLIPIDS | NATTERMANN, A. & CIE. GMBH (DE) | 1990-11-01 | — | — | WO | claimed |
| US-4948589-A | CHOLINE COATED WITH HYDROPHOBIC FILM FOR DELAYED DISSOLVING | SHOWA DENKO KABUSHIKI KAISHA (JP) | 1990-08-14 | — | — | US | claimed |
| US-4917685-A | POROUS MEMBRANE CONFINING ACTIVE MATERIALS AND STABILIZERS | INTERNATIONAL MINERALS & CHEM. CORP. | 1990-04-17 | — | — | US | claimed |
| US-4816568-A | AMINO ACIDS, POLYPEPTIDES, CHOLINE SALTS | INTERNATIONAL MINERALS & CHEMICAL CORP. (US) | 1989-03-28 | — | — | US | claimed |
| EP-0303746-A1 | Stabilization of growth promoting hormones | Mallinckrodt Group Inc. (US) | 1989-02-22 | — | — | EP | claimed |
| EP-0274425-A2 | Pyruvate oxidase, its preparation and use | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1988-07-13 | — | — | EP | claimed |
| CN-87103560-A | Pharmaceutical composition | — | 1988-05-18 | — | — | CN | claimed |
| EP-0146017-A1 | Plant growth regulator and method for increasing crop yields and promoting root formation | MITSUBISHI GAS CHEMICAL COMPANY, INC. (JP) | 1985-06-26 | — | — | EP | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-12635684-B2 | Methods and compositions for biopreservation | IGFBP1, IGFBP2, IL36G | ADORA3 4501/4885MEN1 1781/4885KMT2A 4804/4885 |
| US-12551441-B2 | Water soluble silicon-containing granulate | SI, GIPR, VIP | ADORA3 2072/4885MEN1 2488/4885KMT2A 3323/4885 |
| US-20260015560-A1 | COMPOSITIONS FOR POST-CMP CLEANING OF MICROELECTRONIC DEVICES | TET2, ASIC1, PIEZO1 | ADORA3 1606/4885MEN1 2976/4885KMT2A 778/4885 |
| US-20260000766-A1 | ULTRASOUND OPTOGENETIC COMPOSITIONS AND METHODS | FUS, ELAVL1, NOTCH2 | ADORA3 3563/4885MEN1 1837/4885KMT2A 2979/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.