Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR1 | P32246 | 2/20 | 0.62 |
| ▸ | CCR5 | P51681 | 2/20 | 0.62 |
| ▸ | CCR8 | P51685 | 2/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.46 |
| ▸ | COPS5 | Q92905 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.39 |
| ▸ | NFKBIA | P25963 | 1/20 | 0.37 |
| ▸ | SLC40A1 | Q9NP59 | 5/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10838838 | 0.81 | CCR1 (0.67) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL8838409 | 0.81 | CCR1 (0.67) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL14842035 | 0.81 | CCR1 (0.67) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL30492603 | 0.78 | CCR1 (1.00) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL686948 | 0.78 | CCR1 (1.00) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL2850764 | 0.76 | PSMD14 (0.65) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL29890061 | 0.74 | CCR1 (0.67) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL6888604 | 0.74 | CCR1 (0.67) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL22326612 | 0.71 | CCR1 (0.62) | CCR1CCR5CCR8PSMD14COPS5 | |
| SCHEMBL9817197 | 0.71 | CCR1 (0.56) | CCR1CCR5CCR8PSMD14COPS5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013052716-A1 | FATTY ACID SYNTHASE INHIBITORS | GLAXOSMITHKLINE LLC (US) | 2013-04-11 | — | — | WO | disclosed |