Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 10/20 | 0.47 |
| ▸ | PSEN2 | P49810 | 10/20 | 0.47 |
| ▸ | APH1B | Q8WW43 | 10/20 | 0.47 |
| ▸ | NCSTN | Q92542 | 10/20 | 0.47 |
| ▸ | APH1A | Q96BI3 | 10/20 | 0.47 |
| ▸ | PSENEN | Q9NZ42 | 10/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842995 | 0.89 | MEN1 (0.60) | HDAC8HDAC6HDAC3MAPTKDM4E | |
| SCHEMBL14842927 | 0.87 | MEN1 (0.62) | HDAC8HDAC6HDAC3MEN1KMT2A | |
| SCHEMBL15969664 | 0.86 | MEN1 (0.67) | MAPTKDM4EHSD17B10MEN1KMT2A | |
| SCHEMBL14853932 | 0.84 | HIF1A (0.52) | HSD17B10EP300HIF1AKMT2APSEN1 | |
| SCHEMBL8364218 | 0.84 | EP300 (0.48) | HDAC8HDAC6HDAC3MAPTKDM4E | |
| SCHEMBL14842485 | 0.84 | MEN1 (0.48) | HDAC8HDAC6HDAC3MAPTKDM4E | |
| SCHEMBL14842489 | 0.84 | MAPT (0.55) | MAPTMEN1KMT2ATP53POLB | |
| SCHEMBL1287427 | 0.84 | MAPT (0.48) | HDAC8HDAC6HDAC3MAPTKDM4E | |
| SCHEMBL14842773 | 0.83 | EP300 (0.48) | MAPTEP300HIF1APSEN1PSEN2 | |
| SCHEMBL8363839 | 0.82 | PSEN1 (0.51) | MAPTKDM4EHSD17B10MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243374-A1 | Novel Sulfonamides | BRIGHAM & WOMENS HOSPITAL (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243374-A1 | Novel Sulfonamides | BRIGHAM & WOMENS HOSPITAL (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140243374-A1 | Novel Sulfonamides | BRIGHAM & WOMENS HOSPITAL (US) | 2014-08-28 | — | — | US | disclosed |
| WO-2013052700-A1 | NOVEL SULFONAMIDES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-04-11 | — | — | WO | disclosed |
| WO-2013052700-A1 | NOVEL SULFONAMIDES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2013-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243374-A1 | Novel Sulfonamides | BACE1, BACE2, GSAP | HDAC8 285/4885HDAC6 532/4885HDAC3 333/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.