Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 7/20 | 0.52 |
| ▸ | PSEN2 | P49810 | 7/20 | 0.52 |
| ▸ | APH1B | Q8WW43 | 7/20 | 0.52 |
| ▸ | NCSTN | Q92542 | 7/20 | 0.52 |
| ▸ | APH1A | Q96BI3 | 7/20 | 0.52 |
| ▸ | PSENEN | Q9NZ42 | 7/20 | 0.52 |
| ▸ | AVPR1B | P47901 | 1/20 | 0.52 |
| ▸ | TAS2R14 | Q9NYV8 | 4/20 | 0.52 |
| ▸ | PTGES | O14684 | 1/20 | 0.52 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842995 | 0.96 | MEN1 (0.60) | MEN1KMT2ANPSR1KDM4EHSD17B10 | |
| SCHEMBL14842203 | 0.92 | MEN1 (0.79) | MEN1KMT2ANPSR1PSEN1PSEN2 | |
| SCHEMBL14842485 | 0.86 | MEN1 (0.48) | MEN1KMT2AKDM4EHSD17B10PSEN1 | |
| SCHEMBL14842437 | 0.86 | HDAC8 (0.50) | MEN1KMT2AKDM4EHSD17B10PSEN1 | |
| SCHEMBL14842844 | 0.85 | MEN1 (0.76) | MEN1KMT2ANPSR1KDM4EHSD17B10 | |
| SCHEMBL5568933 | 0.85 | PSEN1 (0.75) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8363839 | 0.84 | PSEN1 (0.51) | MEN1KMT2AKDM4EHSD17B10PSEN1 | |
| SCHEMBL15981121 | 0.83 | MEN1 (0.48) | MEN1KMT2AKDM4EHSD17B10PSEN1 | |
| SCHEMBL8363935 | 0.83 | MEN1 (0.46) | MEN1KMT2AKDM4EHSD17B10PSEN1 | |
| SCHEMBL26159101 | 0.83 | PTGES (0.68) | MEN1KMT2ANPSR1PSEN1PSEN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140243374-A1 | Novel Sulfonamides | BRIGHAM & WOMENS HOSPITAL (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140243374-A1 | Novel Sulfonamides | BACE1, BACE2, GSAP | MEN1 2751/4885KMT2A 1573/4885NPSR1 858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.