Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EP300 | Q09472 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 5/20 | 0.42 |
| ▸ | PSEN2 | P49810 | 5/20 | 0.42 |
| ▸ | APH1B | Q8WW43 | 5/20 | 0.42 |
| ▸ | NCSTN | Q92542 | 5/20 | 0.42 |
| ▸ | APH1A | Q96BI3 | 5/20 | 0.42 |
| ▸ | PSENEN | Q9NZ42 | 5/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RORC | P51449 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8363917 | 0.94 | MEN1 (0.45) | EP300HIF1AHSD17B10KDM4EPSEN1 | |
| SCHEMBL8364235 | 0.90 | EP300 (0.45) | EP300HIF1AHSD17B10KDM4EPSEN1 | |
| SCHEMBL8363935 | 0.89 | MEN1 (0.46) | EP300HIF1AHSD17B10KDM4EPSEN1 | |
| SCHEMBL8364321 | 0.86 | KDM4E (0.45) | HSD17B10KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL8364220 | 0.85 | MEN1 (0.45) | EP300HIF1AHSD17B10KDM4EPSEN1 | |
| SCHEMBL8360870 | 0.85 | NR1D1 (0.48) | HSD17B10KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL8363845 | 0.84 | LMNA (0.49) | HSD17B10KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL8364270 | 0.84 | PSEN1 (0.44) | HSD17B10KDM4EPSEN1PSEN2APH1B | |
| SCHEMBL14842437 | 0.84 | HDAC8 (0.50) | EP300HIF1AHSD17B10KDM4EPSEN1 | |
| SCHEMBL8364319 | 0.83 | MAPT (0.49) | PSEN1PSEN2APH1BNCSTNAPH1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003013527-A1 | SULFONAMIDE DERIVATIVES AS GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION (US) | 2003-02-20 | — | — | WO | disclosed |