Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 17/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 13/20 | 0.37 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.32 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.32 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.32 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.32 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.32 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15968030 | 0.86 | SYK (0.40) | SYKKCNH2ZAP70CYP2D6CHEK1 | |
| SCHEMBL15968031 | 0.86 | SYK (0.40) | SYKKCNH2ZAP70CYP2D6CHEK1 | |
| SCHEMBL17745696 | 0.83 | SYK (0.44) | SYKKCNH2ZAP70 | |
| SCHEMBL17745697 | 0.83 | JAK2 (0.33) | SYKKCNH2 | |
| SCHEMBL14851057 | 0.83 | JAK3 (0.39) | SYKKCNH2ZAP70 | |
| SCHEMBL17745674 | 0.78 | SYK (0.51) | SYKKCNH2ZAP70CYP2D6 | |
| SCHEMBL14842454 | 0.78 | SYK (0.33) | SYKKCNH2ZAP70DYRK3CSNK2A2 | |
| SCHEMBL15968322 | 0.77 | SYK (0.42) | SYKKCNH2ZAP70CYP2D6 | |
| SCHEMBL14976231 | 0.72 | JAK3 (0.42) | SYKCHEK1 | |
| SCHEMBL15968495 | 0.72 | SYK (0.39) | SYKKCNH2ZAP70 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763976-B1 | 2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME (US) | 2016-05-18 | — | — | EP | disclosed |
| EP-2763976-A1 | 2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013052394-A1 | 2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2013-04-11 | — | — | WO | disclosed |