Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 2/20 | 0.33 |
| ▸ | JAK1 | P23458 | 2/20 | 0.33 |
| ▸ | AR | P10275 | 2/20 | 0.33 |
| ▸ | SYK | P43405 | 6/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.31 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14842452 | 0.83 | SYK (0.37) | SYKKCNH2 | |
| SCHEMBL15644804 | 0.80 | SYK (0.37) | JAK2JAK1ARSYKKCNH2 | |
| SCHEMBL15644802 | 0.80 | SYK (0.37) | JAK2JAK1ARSYKKCNH2 | |
| SCHEMBL17745696 | 0.78 | SYK (0.44) | JAK2JAK1SYKKCNH2 | |
| SCHEMBL14976231 | 0.78 | JAK3 (0.42) | SYKJAK3IRAK4 | |
| SCHEMBL14851183 | 0.78 | JAK3 (0.44) | ARSYKJAK3 | |
| SCHEMBL495857 | 0.74 | MEN1 (0.31) | — | |
| SCHEMBL15968485 | 0.73 | SYK (0.43) | SYKKCNH2IRAK4 | |
| SCHEMBL496358 | 0.71 | CHEK1 (0.36) | AR | |
| SCHEMBL495955 | 0.71 | MEN1 (0.33) | ARIRAK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763976-B1 | 2-PYRIDYL CARBOXAMIDE-CONTAINING SPLEEN TYROSINE KINASE (SYK) INHIBITORS | MERCK SHARP & DOHME (US) | 2016-05-18 | — | — | EP | disclosed |