Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 15/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 14/20 | 0.62 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14843472 | 0.91 | MTOR (0.62) | MTORPIK3CAPIK3CB | |
| SCHEMBL14842740 | 0.87 | MTOR (0.53) | MTORPIK3CA | |
| SCHEMBL14843227 | 0.83 | MTOR (0.67) | MTORPIK3CAPIK3CB | |
| SCHEMBL14843596 | 0.83 | MTOR (0.47) | MTORPIK3CA | |
| SCHEMBL14843229 | 0.81 | MTOR (0.78) | MTORPIK3CAPIK3CB | |
| SCHEMBL14842905 | 0.81 | MTOR (0.57) | MTORPIK3CA | |
| SCHEMBL14843064 | 0.81 | MTOR (0.57) | MTORPIK3CA | |
| SCHEMBL17836772 | 0.81 | MTOR (0.57) | MTORPIK3CA | |
| SCHEMBL14842902 | 0.81 | MTOR (0.57) | MTORPIK3CA | |
| SCHEMBL14843222 | 0.81 | MTOR (0.57) | MTORPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2763985-B1 | {(4-(4-MORPHOLINO-DIHYDROTHIENO[3,4-D]PYRIMIDIN-2-YL)ARYL}UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LTD (GB) | 2016-06-22 | — | — | EP | claimed |
| EP-2763985-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | Cellzome Limited (GB) | 2014-08-13 | — | — | EP | disclosed |
| WO-2013050508-A1 | MORPHOLINO SUBSTITUTED BICYCLIC PYRIMIDINE UREA OR CARBAMATE DERIVATIVES AS MTOR INHIBITORS | CELLZOME LIMITED (GB) | 2013-04-11 | — | — | WO | disclosed |