Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 3/20 | 0.38 |
| ▸ | GGPS1 | O95749 | 5/20 | 0.36 |
| ▸ | FDPS | P14324 | 7/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1484417 | 0.96 | CA2 (0.42) | CES2CA2CES1GGPS1FDPS | |
| SCHEMBL337752 | 0.96 | CA2 (0.42) | CES2CA2CES1GGPS1FDPS | |
| Potassium Ion SCHEMBL1484421 | 0.96 | CES2 (0.38) | CES2CA2CES1GGPS1FDPS | |
| SCHEMBL7178944 | 0.96 | CA2 (0.42) | CES2CA2CES1GGPS1FDPS | |
| SCHEMBL7199650 | 0.82 | CA2 (0.42) | CES2CA2CES1GGPS1FDPS | |
| SCHEMBL5342660 | 0.81 | CES2 (0.40) | CES2GGPS1 | |
| SCHEMBL3052895 | 0.81 | CES2 (0.40) | CES2GGPS1 | |
| SCHEMBL11660121 | 0.81 | CES2 (0.40) | CES2GGPS1 | |
| SCHEMBL27508982 | 0.81 | CES2 (0.40) | CES2GGPS1 | |
| SCHEMBL27615120 | 0.81 | CES2 (0.40) | CES2GGPS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110082118-A1 | Onychomycosis Treatment Delivery System | PRUGEN IP HOLDINGS, INC | 2011-04-07 | — | — | US | disclosed |
| US-20110076261-A1 | Antifungal Drug Delivery System | PRUGEN IP HOLDINGS, INC | 2011-03-31 | — | — | US | disclosed |
| US-20080317737-A1 | Drug combination for the treatment of skin disorders | PRUGEN, INC. | 2008-12-25 | — | — | US | disclosed |
| US-4292035-A | COMPLEX OF SMECTITE CLAYS, AMINES, AND ORGANIC SULFONIUM, PHOSPHONIUM, OR QUATERNARY AMMONIUM COMPOUNDS, WITH AN ANIONIC SURFACTANT | THE PROCTER & GAMBLE COMPANY (US) | 1981-09-29 | — | — | US | disclosed |
| US-4062647-A | Clay-containing fabric softening detergent compositions | THE PROCTER & GAMBLE COMPANY (US) | 1977-12-13 | — | — | US | disclosed |
| US-4051046-A | ANTISTATIC AGENTS, SOFTENERS, WRINKLE RESISTANCE | THE PROCTER & GAMBLE COMPANY (US) | 1977-09-27 | — | — | US | disclosed |