Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KLK7 | P49862 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14816941 | 1.00 | HSD17B10 (0.62) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL29935483 | 0.89 | HSD17B10 (0.60) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL28953620 | 0.89 | HSD17B10 (0.60) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL14748405 | 0.87 | HSD17B10 (0.58) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL67044 | 0.87 | HSD17B10 (0.69) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL6219872 | 0.87 | HSD17B10 (0.69) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL27877016 | 0.87 | HSD17B10 (0.69) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL85536 | 0.87 | HSD17B10 (0.69) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL67045 | 0.87 | HSD17B10 (0.69) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 | |
| SCHEMBL20492528 | 0.85 | HSD17B10 (0.68) | HSD17B10SMN1; SMN2NPC1LMNANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8415482-B2 | Proline derivatives | NATIONAL HEALTH RESEARCH INSTITUTES (TW) | 2013-04-09 | — | — | US | disclosed |