Tromantadine

Tromantadine

SCHEMBL148486

CN(C)CCOCC(=O)NC12CC3CC(CC(C3)C1)C2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
OPRK1 P41145 1/20 1.00
ALDH1A1 P00352 5/20 0.52
KMT2A Q03164 3/20 0.52
MAPT P10636 2/20 0.52
SMN1; SMN2 Q16637 2/20 0.52
MEN1 O00255 2/20 0.52
NPSR1 Q6W5P4 1/20 0.52
LMNA P02545 1/20 0.52
THRB P10828 1/20 0.52
HTT P42858 1/20 0.52
EPHX2 P34913 5/20 0.49
ATM Q13315 1/20 0.49
HDAC3 O15379 1/20 0.44
HDAC4 P56524 1/20 0.44
HDAC1 Q13547 1/20 0.44
HDAC7 Q8WUI4 1/20 0.44
HDAC2 Q92769 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC11 Q96DB2 1/20 0.44
HDAC8 Q9BY41 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tromantadine SCHEMBL1376070 0.99 OPRK1 (0.97) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
Tromantadine SCHEMBL1651361 0.97 OPRK1 (0.94) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
Tromantadine SCHEMBL2454301 0.90 OPRK1 (0.81) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL18201484 0.81 OPRK1 (0.68) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL23960193 0.80 OPRK1 (0.66) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL3455397 0.80 OPRK1 (0.66) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL11355333 0.76 OPRK1 (0.61) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL23846112 0.76 OPRK1 (0.61) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2
SCHEMBL4229110 0.75 ATM (0.65) OPRK1ALDH1A1KMT2ASMN1; SMN2LMNA
SCHEMBL14777837 0.73 OPRK1 (0.58) OPRK1ALDH1A1KMT2AMAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 6765 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20260139860-A1 PRODUCTS OF MANUFACTURE FOR THE TREATMENT, PREVENTION AND AMELIORATION OF MICROBIAL INFECTIONS CENTRE FOR DIGESTIVE DISEASES (AU) 2026-05-21 US claimed
EP-4094767-B1 NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO UNIV EMORY (US) 2026-05-20 EP claimed
US-20260108619-A1 CONJUGATION LINKERS, CELL BINDING MOLECULE-DRUG CONJUGATES CONTAINING THE LINKERS, METHODS OF MAKING AND USES SUCH CONJUGATES WITH THE LINKERS HANGZHOU DAC BIOTECH CO., LTD. (CN) 2026-04-23 US claimed
US-20260102422-A1 4'-HALOGEN CONTAINING NUCLEOTIDE AND NUCLEOSIDE THERAPEUTIC COMPOSITIONS AND USES RELATED THERETO UNIV EMORY (US) 2026-04-16 US claimed
US-12595280-B2 Phosphoramidates for the treatment of hepatitis B virus EMORY UNIVERSITY (US) 2026-04-07 US claimed
US-20260091068-A1 METHODS FOR TREATING AND PREVENTING DISEASES Tets, Viktor Veniaminovich (US) 2026-04-02 US claimed
US-20260092059-A1 Broad Spectrum Antiviral Compositions and Methods EVRYS BIO, LLC (US) 2026-04-02 US claimed
EP-3534910-B1 RIFAMPICIN DERIVATIVES WITH ANTIBACTERIAL ACTIVITY POP TEST ONCOLOGY LLC (US) 2026-03-25 EP claimed
US-12576124-B2 Formulation of a conjugate of a tubulysin analog to a cell-binding molecule HANGZHOU DAC BIOTECH CO., LTD (CN) 2026-03-17 US claimed
US-20260060964-A1 METHODS AND COMPOSITIONS FOR TREATING SEPSIS ANTIVIRUS THERAPEUTICS (US) 2026-03-05 US claimed
EP-0870757-A2 Fluoro-substituted adamantane derivatives PFIZER INC. (US) 1998-10-14 EP claimed
US-5811078-A IN A SOLVENT MIXTURE WITH ETHYL OR ISOPROPYL ALCOHOL AND WATER ADOLOR CORPORATION (US) 1998-09-22 US claimed
EP-0852494-A2 PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1998-07-15 EP claimed
WO-1997029735-A1 DERMAL PENETRATION ENHANCERS AND DRUG DELIVERY SYSTEMS INVOLVING SAME MONASH UNIVERSITY (AU) 1997-08-21 WO claimed
EP-0599188-B1 Trans and CIS traumatic acid salts having cicatrizant activity associated to bacteriostatic, antiviral, antibiotic or antifungal activity LIFEGROUP SPA (IT) 1997-08-06 EP claimed
WO-1997009973-A2 PERIPHERALLY ACTIVE ANTI-HYPERALGESIC OPIATES THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 1997-03-20 WO claimed
US-5567716-A FOR THE THERAPEUTIC TREATMENT OF CUTANEOUS PATHOLOGIES LIFEGROUP S.P.A. (IT) 1996-10-22 US claimed
CN-1129573-A Antiviral Drug Acyclovir Percutaneous Absorption Preparation HU YOUPU (CN) 1996-08-28 CN claimed
EP-0509338-B1 Manufacture and use of stable preparations of small-sized liposomes MERZ & CO GMBH & CO (DE) 1995-08-16 EP claimed
EP-0599188-A1 Trans and CIS traumatic acid salts having cicatrizant activity associated to bacteriostatic, antiviral, antibiotic or antifungal activity LIFEGROUP S.p.A. (IT) 1994-06-01 EP claimed