Known targets — ChEMBL curated mechanism
DHFRGARTPTGFRPTGIRPTGS1PTGS2TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8envmurAthyA
The experimentally established mechanism targets of Tromantadine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRK1 | P41145 | 1/20 | 0.81 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tromantadine SCHEMBL148486 | 0.90 | OPRK1 (1.00) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| Tromantadine SCHEMBL1376070 | 0.89 | OPRK1 (0.97) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| Tromantadine SCHEMBL1651361 | 0.87 | OPRK1 (0.94) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL18201484 | 0.72 | OPRK1 (0.68) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23960193 | 0.72 | OPRK1 (0.66) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL3455397 | 0.72 | OPRK1 (0.66) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL11355333 | 0.69 | OPRK1 (0.61) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| Trolamine SCHEMBL11359317 | 0.69 | OPRK1 (0.58) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL23846112 | 0.69 | OPRK1 (0.61) | OPRK1ALDH1A1MAPTMEN1KMT2A | |
| SCHEMBL4229110 | 0.67 | ATM (0.65) | OPRK1ALDH1A1KMT2ALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9687864-B2 | System and method for enhanced electrostatic deposition and surface coatings | BATTELLE MEMORIAL INSTITUTE (US) | 2017-06-27 | — | — | US | disclosed |
| US-20150040827-A1 | SYSTEM AND METHOD FOR ENHANCED ELECTROSTATIC DEPOSITION AND SURFACE COATINGS | MICELL MEDTECH INC. | 2015-02-12 | — | — | US | disclosed |
| US-8795762-B2 | System and method for enhanced electrostatic deposition and surface coatings | BATTELLE MEMORIAL INSTITUTE (US) | 2014-08-05 | — | — | US | disclosed |
| US-20110238161-A1 | SYSTEM AND METHOD FOR ENHANCED ELECTROSTATIC DEPOSITION AND SURFACE COATINGS | BATTELLE MEMORIAL INSTITUTE (US) | 2011-09-29 | — | — | US | disclosed |