Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PPIA | P62937 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2601270 | 0.76 | NPC1 (0.52) | L3MBTL1ALDH1A1KDM4EPOLBNPC1 | |
| SCHEMBL2494002 | 0.76 | RAB9A (0.59) | L3MBTL1ALDH1A1GFERKDM4ELMNA | |
| SCHEMBL510235 | 0.75 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL5044753 | 0.75 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL29431831 | 0.75 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL8613491 | 0.75 | L3MBTL1 (0.53) | L3MBTL1ALDH1A1GFERKDM4ELMNA | |
| SCHEMBL28729464 | 0.75 | L3MBTL1 (0.47) | L3MBTL1ALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL18640774 | 0.74 | DHODH (0.55) | L3MBTL1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL26054502 | 0.74 | L3MBTL1 (0.49) | L3MBTL1ALDH1A1KDM4ELMNACYP1A2 | |
| SCHEMBL2556765 | 0.74 | L3MBTL1 (0.46) | L3MBTL1ALDH1A1KDM4ECYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140206671-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2014-07-24 | — | — | US | disclosed |
| US-20130090331-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090331-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | JAK2, JAK1, JAK3 | L3MBTL1 1754/4885ALDH1A1 3869/4885GFER 3430/4885 |
| US-20140206671-A1 | TRICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF JANUS KINASE | JAK2, JAK1, JAK3 | L3MBTL1 1754/4885ALDH1A1 3869/4885GFER 3430/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.