Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.51 |
| ▸ | CYP11B1 | P15538 | 10/20 | 0.49 |
| ▸ | CYP11B2 | P19099 | 9/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | CCR1 | P32246 | 1/20 | 0.48 |
| ▸ | CCR5 | P51681 | 1/20 | 0.48 |
| ▸ | CCR8 | P51685 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.46 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.46 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 3/20 | 0.43 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22454022 | 0.84 | NPC1 (0.56) | CYP3A4CYP2A6CYP1A2CYP2C9CCR1 | |
| SCHEMBL16835818 | 0.82 | CYP11B1 (0.48) | CYP3A4CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL31403032 | 0.82 | GRM5 (0.49) | CYP3A4CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL3422235 | 0.80 | CYP2A6 (0.59) | CYP3A4CYP2A6CYP11B1CYP11B2CCR1 | |
| SCHEMBL12019038 | 0.80 | KDM1A (0.58) | CYP3A4CYP2A6CYP1A2CCR1CCR5 | |
| SCHEMBL14848469 | 0.80 | CYP11B1 (0.46) | CYP3A4CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL765406 | 0.79 | RXFP1 (0.58) | CYP3A4CYP2A6CYP11B1CCR1CCR5 | |
| SCHEMBL15296276 | 0.79 | CYP11B1 (0.64) | CYP3A4CYP11B1CYP11B2CYP1A2CYP2C9 | |
| SCHEMBL15344161 | 0.79 | CYP2A6 (0.57) | CYP3A4CYP2A6CYP11B1CYP11B2CYP1A2 | |
| SCHEMBL23905067 | 0.78 | CYP11B1 (0.48) | CYP3A4CYP2A6CYP11B1CYP11B2CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2582676-B1 | TETRAHYDROQUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME (US) | 2016-12-14 | — | — | EP | disclosed |
| US-8815902-B2 | Tetrahydroquinoline amide M1 receptor positive allosteric modulators | MERCK SHARP & DOHME CORP. (US) | 2014-08-26 | — | — | US | disclosed |
| US-20130090352-A1 | TETRAHYDROQUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | MERCK SHARP & DOHME LLC | 2013-04-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130090352-A1 | TETRAHYDROQUINOLINE AMIDE M1 RECEPTOR POSITIVE ALLOSTERIC MODULATORS | CHRM1, OPRL1, OPRM1 | CYP3A4 709/4885CYP2A6 671/4885CYP11B1 1408/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.