SCHEMBL765406

SCHEMBL765406

COc1ccc(-c2ccc(C)cn2)cc1

nearest known ligand 0.58

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RXFP1 Q9HBX9 1/20 0.58
CCR1 P32246 1/20 0.56
CCR5 P51681 1/20 0.56
CCR8 P51685 1/20 0.56
HDAC6 Q9UBN7 1/20 0.56
NPC1 O15118 4/20 0.54
RAB9A P51151 4/20 0.54
CASP3 P42574 3/20 0.54
SENP7 Q9BQF6 3/20 0.54
SENP8 Q96LD8 1/20 0.54
SENP6 Q9GZR1 1/20 0.54
ALDH1A1 P00352 1/20 0.54
GAA P10253 1/20 0.54
TDP1 Q9NUW8 1/20 0.54
ACHE P22303 1/20 0.52
EGFR P00533 1/20 0.49
KDR P35968 1/20 0.49
KMT2A Q03164 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2A6 P11509 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12277217 0.89 RXFP1 (0.55) RXFP1NPC1RAB9ACASP3SENP7
SCHEMBL17754087 0.89 RXFP1 (0.54) RXFP1CCR1CCR5CCR8HDAC6
SCHEMBL11129508 0.86 ACHE (0.60) RXFP1NPC1RAB9ACASP3SENP7
SCHEMBL17051514 0.85 CCR1 (0.75) RXFP1CCR1CCR5CCR8HDAC6
SCHEMBL16656143 0.84 CCR1 (0.67) RXFP1CCR1CCR5CCR8HDAC6
SCHEMBL3716990 0.84 RXFP1 (0.62) RXFP1NPC1RAB9ACASP3SENP7
SCHEMBL2477927 0.83 CCR1 (0.71) CCR1CCR5CCR8HDAC6NPC1
SCHEMBL22454022 0.83 NPC1 (0.56) CCR1CCR5CCR8HDAC6NPC1
SCHEMBL12393774 0.82 APP (0.61) RXFP1CCR1CCR5CCR8HDAC6
SCHEMBL10000248 0.81 CCR1 (0.68) CCR1CCR5CCR8HDAC6NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 34 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-102574870-B Luminescent gold (III) compound containing bidentate ligand for organic light-emitting device and preparation method thereof THE UNIVERSITY OF HONG KONG (CN) 2016-05-18 CN claimed
US-8372977-B2 Luminescent gold(III) compounds containing bidentate ligand for organic light-emitting devices and their preparation THE UNIVERSITY OF HONG KONG (CN) 2013-02-12 US claimed
US-20110012093-A1 LUMINESCENT GOLD(III) COMPOUNDS CONTAINING BIDENTATE LIGAND FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION THE UNIVERSITY OF HONG KONG (CN) 2011-01-20 US claimed
WO-2011006353-A1 LUMINESCENT GOLD(III) COMPOUNDS CONTAINING BIDENTATE LIGAND FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION THE UNIVERSITY OF HONG KONG (CN) 2011-01-20 WO claimed
US-12022832-B2 Compounds and methods for treating nematode infections THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2024-07-02 US disclosed
US-11890604-B2 Composite catalyst for carbon dioxide reduction and method of fabricating of the same KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS (KR) 2024-02-06 US disclosed
US-20210220809-A1 COMPOSITE CATALYST FOR CARBON DIOXIDE REDUCTION AND METHOD OF FABRICATING OF THE SAME KOREA UNIVERSITY RESEARCH AND BUSINESS FOUNDATION, SEJONG CAMPUS (KR) 2021-07-22 US disclosed
WO-2020051689-A1 COMPOUNDS AND METHODS FOR TREATING NEMATODE INFECTIONS THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTO (CA) 2020-03-19 WO disclosed
CN-109912567-A A kind of biaryl pyrrole derivatives compound and preparation method thereof 台州职业技术学院 2019-06-21 CN disclosed
US-20190058132-A1 ORGANIC LIGHT-EMITTING DEVICE AND APPARATUS INCLUDING THE SAME SAMSUNG DISPLAY CO., LTD. (KR) 2019-02-21 US disclosed
CN-102574870-B Luminescent gold (III) compound containing bidentate ligand for organic light-emitting device and preparation method thereof THE UNIVERSITY OF HONG KONG (CN) 2016-05-18 CN disclosed
US-20130109652-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS ADDEX PHARMACEUTICALS S.A. (CH) 2013-05-02 US disclosed
EP-0428720-B1 OPTICALLY ACTIVE COMPOUNDS AND LIQUID CRYSTAL PHASE MERCK PATENT GMBH (DE) 1995-03-22 EP disclosed
US-5393459-A Optically active compounds, and a liquid-crystalline phase MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 1995-02-28 US disclosed
US-5167859-A Electrooptical display elements MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) 1992-12-01 US disclosed
EP-0283490-B1 PROCESS FOR THE PRODUCTION OF ETHANE DERIVATIVES MERCK PATENT GmbH (DE) 1992-01-08 EP disclosed
EP-0428720-A1 OPTICALLY ACTIVE COMPOUNDS AND LIQUID CRYSTAL PHASE. MERCK PATENT GMBH (DE) 1991-05-29 EP disclosed
WO-1990013611-A2 OPTICALLY ACTIVE COMPOUNDS AND LIQUID CRYSTAL PHASE MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1990-11-15 WO disclosed
EP-0283490-A1 PROCESS FOR THE PRODUCTION OF ETHANE DERIVATIVES. MERCK PATENT GMBH (DE) 1988-09-28 EP disclosed
WO-1988002364-A2 PROCESS FOR THE PRODUCTION OF ETHANE DERIVATIVES MERCK Patent Gesellschaft mit beschränkter Haftung (DE) 1988-04-07 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12022832-B2 Compounds and methods for treating nematode infections HNMT, NISCH, HRH2 RXFP1 1194/4885CCR1 1016/4885CCR5 1571/4885
US-20110012093-A1 LUMINESCENT GOLD(III) COMPOUNDS CONTAINING BIDENTATE LIGAND FOR ORGANIC LIGHT-EMITTING DEVICES AND THEIR PREPARATION CHRM1, CHRM5, CHRM2 RXFP1 1789/4885CCR1 741/4885CCR5 113/4885
US-20130109652-A1 NOVEL PYRIDINONE DERIVATIVES AND THEIR USE AS POSITIVE ALLOSTERIC MODULATORS OF MGLUR2-RECEPTORS GRM2, GRM1, GRIA2 RXFP1 443/4885CCR1 2999/4885CCR5 1686/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.