Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | BCAT2 | O15382 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CDC7 | O00311 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | MKNK1 | Q9BUB5 | 2/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 2/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.37 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.37 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4560246 | 0.87 | NTRK1 (0.43) | NTRK1PIM1BCAT2MEN1GAA | |
| SCHEMBL23199045 | 0.80 | NTRK1 (0.52) | NTRK1PIM1BCAT2MEN1GAA | |
| SCHEMBL14917462 | 0.78 | MKNK1 (0.49) | NTRK1PIM1BCAT2MEN1GAA | |
| Acetic Acid SCHEMBL27846617 | 0.77 | NTRK1 (0.50) | NTRK1PIM1BCAT2MEN1GAA | |
| SCHEMBL25275838 | 0.76 | BCAT2 (0.44) | NTRK1PIM1BCAT2MEN1GAA | |
| SCHEMBL28143127 | 0.76 | CDC7 (0.46) | NTRK1PIM1BCAT2MEN1GAA | |
| SCHEMBL1533660 | 0.76 | NTRK1 (0.43) | NTRK1PIM1BCAT2MEN1GAA | |
| SCHEMBL1591434 | 0.76 | NTRK1 (0.33) | NTRK1PIM1CDC7MKNK1MKNK2 | |
| SCHEMBL23116461 | 0.76 | SIRT3 (0.41) | NTRK1PIM1POLBPKMYT1HSP90AA1 | |
| SCHEMBL9215517 | 0.76 | KDM4E (0.39) | NTRK1PIM1CDC7HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2579717-A2 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | Merck Sharp & Dohme Corp. (US) | 2013-04-17 | — | — | EP | disclosed |
| WO-2011156245-A2 | POSITIVE ALLOSTERIC MODULATORS OF MGLUR2 | MERCK SHARP & DOHME CORP. (US) | 2011-12-15 | — | — | WO | disclosed |