Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.74 |
| ▸ | CISD1 | Q9NZ45 | 3/20 | 0.68 |
| ▸ | MAOA | P21397 | 1/20 | 0.68 |
| ▸ | NAT1 | P18440 | 3/20 | 0.68 |
| ▸ | CA2 | P00918 | 1/20 | 0.68 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.68 |
| ▸ | MTOR | P42345 | 2/20 | 0.66 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.66 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.66 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.66 |
| ▸ | GAA | P10253 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.65 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | PIM1 | P11309 | 2/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.57 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.57 |
| ▸ | CLK1 | P49759 | 1/20 | 0.57 |
| ▸ | CLK3 | P49761 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8307310 | 1.00 | GSK3B (0.74) | GSK3BCISD1MAOANAT1CA2 | |
| SCHEMBL23094695 | 0.85 | GSK3B (1.00) | GSK3BCISD1MAOAMTORTDP1 | |
| SCHEMBL6415601 | 0.82 | GSK3B (0.74) | GSK3BTDP1GAAL3MBTL1MAPT | |
| SCHEMBL6415604 | 0.82 | GSK3B (0.74) | GSK3BTDP1GAAL3MBTL1MAPT | |
| SCHEMBL8310399 | 0.81 | CISD1 (1.00) | GSK3BCISD1MAOANAT1CA2 | |
| SCHEMBL8310397 | 0.81 | CISD1 (1.00) | GSK3BCISD1MAOANAT1CA2 | |
| SCHEMBL4416451 | 0.81 | NAT1 (1.00) | CISD1MAOANAT1CA2EPHX1 | |
| SCHEMBL1812224 | 0.81 | NAT1 (1.00) | CISD1MAOANAT1CA2EPHX1 | |
| SCHEMBL3491175 | 0.81 | NAT1 (1.00) | CISD1MAOANAT1CA2EPHX1 | |
| SCHEMBL23036936 | 0.80 | MTOR (1.00) | GSK3BCISD1MAOANAT1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0915090-A1 | Compounds useful as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1999-05-12 | — | — | EP | disclosed |
| US-5716975-A | NONTOXIC RHODANINE DERIVATIVES; ANTIDIABETIC AGENTS, CATHEPSIN D INHIBITORS, B-AMYLOID PROTEIN REDUCTION | ELI LILLY AND COMPANY (US) | 1998-02-10 | — | — | US | disclosed |
| US-5661168-A | ADMINISTERING RHODANINE DERIVATIVES TO CONTROL DIABETES | ELI LILLY AND COMPANY (US) | 1997-08-26 | — | — | US | disclosed |
| US-5523314-A | RHODANINE DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-06-04 | — | — | US | disclosed |
| EP-0587377-A2 | Thiazolidinone derivatives as hypoglycemic agents and for treating Alzheimer's disease | ELI LILLY AND COMPANY (US) | 1994-03-16 | — | — | EP | disclosed |