Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 3/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.39 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.39 |
| ▸ | PRKACA | P17612 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | GSK3A | P49840 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5228165 | 0.86 | KMT2A (0.59) | KCNA5KCNH2KMT2ASCN9ADPP4 | |
| SCHEMBL14863120 | 0.86 | KCNA5 (0.62) | KCNA5KCNH2KMT2ASCN9AALDH1A1 | |
| SCHEMBL14862843 | 0.80 | CASP6 (0.40) | KCNA5KCNH2KMT2ASCN9AALDH1A1 | |
| SCHEMBL22189969 | 0.80 | KMT2A (0.57) | KCNA5KCNH2KMT2AMAPTMAPK1 | |
| SCHEMBL22189968 | 0.80 | KMT2A (0.57) | KCNA5KCNH2KMT2AMAPTMAPK1 | |
| SCHEMBL477401 | 0.76 | KCNA5 (0.51) | KCNA5KCNH2KMT2ANPC1ALDH1A1 | |
| SCHEMBL14863737 | 0.75 | SMARCA2 (0.45) | KMT2AIRAK1PRKCIHDAC8 | |
| Methane SCHEMBL28852242 | 0.74 | KCNA5 (0.50) | KCNA5KCNH2KMT2ANPC1ALDH1A1 | |
| SCHEMBL3288611 | 0.74 | DPP4 (0.69) | KCNA5KCNH2MAPTHSD17B10DPP4 | |
| SCHEMBL5742166 | 0.74 | CYP1A2 (0.48) | ALDH1A1HSD17B10DPP4SLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013056015-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |