Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMARCA2 | P51531 | 1/20 | 0.45 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 8/20 | 0.41 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.39 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | BTK | Q06187 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | DRD1 | P21728 | 1/20 | 0.38 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25022660 | 0.78 | DPP4 (0.52) | SMARCA2SMARCA4BRD4PDK2ALOX5AP | |
| SCHEMBL5228165 | 0.77 | KMT2A (0.59) | KMT2A | |
| SCHEMBL14863738 | 0.77 | CCNC (0.46) | HDAC8 | |
| SCHEMBL31048702 | 0.76 | BRD4 (0.54) | SMARCA2SMARCA4BRD4PDK2ALOX5AP | |
| SCHEMBL20777560 | 0.76 | SMARCA2 (0.47) | SMARCA2SMARCA4BRD4PDK2ALOX5AP | |
| SCHEMBL14863029 | 0.75 | KCNA5 (0.54) | HDAC8PRKCIIRAK1KMT2A | |
| SCHEMBL20773248 | 0.75 | CFD (0.52) | SMARCA2SMARCA4BRD4PDK2GRM2 | |
| SCHEMBL14860265 | 0.75 | CTSV (0.49) | HDAC8IRAK1IRAK4 | |
| SCHEMBL14863120 | 0.74 | KCNA5 (0.62) | KMT2A | |
| SCHEMBL31181988 | 0.74 | BRD4 (0.48) | SMARCA2SMARCA4BRD4PDK2ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2013056015-A1 | ISOINDOLINONE AND PYRROLOPYRIDINONE DERIVATIVES AS AKT INHIBITORS | INCYTE CORPORATION (US) | 2013-04-18 | — | — | WO | disclosed |