Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 2/20 | 0.51 |
| ▸ | PARP1 | P09874 | 2/20 | 0.49 |
| ▸ | CSF1R | P07333 | 1/20 | 0.42 |
| ▸ | FLT1 | P17948 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.41 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.41 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.40 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.40 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.39 |
| ▸ | ICMT | O60725 | 2/20 | 0.39 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.38 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13412869 | 0.81 | NR4A2 (0.36) | DHODHPARP1NR4A2BRD4BRD9 | |
| SCHEMBL1852275 | 0.79 | TSHR (0.54) | HDAC2 | |
| SCHEMBL12394209 | 0.77 | DHODH (0.64) | DHODHPARP1CSF1RFLT1FLT3 | |
| SCHEMBL5605353 | 0.75 | PARP1 (0.78) | DHODHPARP1CSF1RFLT1FLT3 | |
| SCHEMBL1848238 | 0.75 | MAP4K4 (0.55) | PARP1BRD4BRD9PARP10 | |
| SCHEMBL7169894 | 0.71 | EGFR (0.46) | DHODH | |
| SCHEMBL3884828 | 0.71 | SMN1; SMN2 (0.58) | — | |
| Terephthalamide SCHEMBL5060544 | 0.71 | PARP1 (0.76) | DHODHPARP1CSF1RFLT1FLT3 | |
| SCHEMBL18120863 | 0.68 | DHODH (1.00) | DHODHPARP1CSF1RFLT1FLT3 | |
| SCHEMBL30108216 | 0.68 | DHODH (0.60) | DHODHPARP1CSF1RFLT1FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420052-B2 | Imaging agents useful for identifying AD pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-04-16 | — | — | US | disclosed |