Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K4 | O95819 | 2/20 | 0.55 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.54 |
| ▸ | PARP1 | P09874 | 2/20 | 0.54 |
| ▸ | CA1 | P00915 | 1/20 | 0.54 |
| ▸ | CA2 | P00918 | 1/20 | 0.54 |
| ▸ | PARP2 | Q9UGN5 | 1/20 | 0.54 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.54 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.51 |
| ▸ | CHEK2 | O96017 | 3/20 | 0.51 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.48 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | BRD9 | Q9H8M2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7442028 | 0.78 | PARP10 (0.88) | MAP4K4PARP10PARP1CA1CA2 | |
| SCHEMBL14864456 | 0.75 | DHODH (0.51) | PARP10PARP1BRD4BRD9 | |
| SCHEMBL28188209 | 0.74 | RXRA (0.71) | MAP4K4PARP10PARP1CA1CA2 | |
| SCHEMBL201761 | 0.73 | PARP10 (1.00) | MAP4K4PARP10PARP1CA1CA2 | |
| SCHEMBL3896372 | 0.71 | ALDH1A3 (0.47) | NPC1RAB9AKDM4EALDH1A1POLB | |
| Hydrochloric Acid SCHEMBL4376056 | 0.71 | PARP10 (0.95) | MAP4K4PARP10PARP1CA1CA2 | |
| Hydrochloric Acid SCHEMBL408766 | 0.71 | PARP10 (0.95) | MAP4K4PARP10PARP1CA1CA2 | |
| SCHEMBL13412869 | 0.70 | NR4A2 (0.36) | PARP10PARP1CHEK2MKNK1MKNK2 | |
| SCHEMBL1847594 | 0.70 | RAB9A (0.61) | NPC1RAB9AKDM4EALDH1A1POLB | |
| SCHEMBL3720494 | 0.70 | PARP1 (0.67) | MAP4K4PARP10PARP1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420052-B2 | Imaging agents useful for identifying AD pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-04-16 | — | — | US | disclosed |
| EP-2323697-A2 | IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY | Siemens Medical Solutions USA, Inc. (US) | 2011-05-25 | — | — | EP | disclosed |
| US-20100098634-A1 | Imaging Agents Useful for Identifying AD Pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. | 2010-04-22 | — | — | US | disclosed |
| WO-2010011964-A2 | IMAGING AGENTS USEFUL FOR IDENTIFYING AD PATHOLOGY | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2010-01-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100098634-A1 | Imaging Agents Useful for Identifying AD Pathology | APP, APBA1, PYGB | MAP4K4 4649/4885PARP10 874/4885PARP1 1211/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.