Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.58 |
| ▸ | NPC1 | O15118 | 4/20 | 0.58 |
| ▸ | RAB9A | P51151 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 2/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.58 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ENPP3 | O14638 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL873426 | 0.82 | ALDH1A1 (0.62) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL942764 | 0.81 | ALDH1A1 (0.65) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL3897325 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL1850566 | 0.79 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL3895951 | 0.79 | ALDH1A1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL30088573 | 0.79 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL29089654 | 0.79 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL1851663 | 0.79 | NPC1 (0.58) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL27278125 | 0.79 | MAPT (0.54) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 | |
| Dimethylamine SCHEMBL7169891 | 0.79 | ALDH1A1 (0.57) | SMN1; SMN2NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108129480-A | A kind of preparation method of the indolizine of methylene containing heteroaromatic derivative | 赵艳阳 | 2018-06-08 | — | — | CN | claimed |
| CN-117265556-A | Electrochemical preparation method and application of 1, 3-diaryl mercapto indolizine derivative | 上海陶术生物科技有限公司 | 2023-12-22 | — | — | CN | disclosed |
| CN-108129480-A | A kind of preparation method of the indolizine of methylene containing heteroaromatic derivative | 赵艳阳 | 2018-06-08 | — | — | CN | disclosed |
| US-8486962-B2 | N-(2-Methoxy-phenyl)-2-oxo-2-(2-phenyl-indolizin-3-yl)-acetamide; antifungal agents; inhibiting Aspergillus | F2G LTD. (GB) | 2013-07-16 | — | — | US | disclosed |
| EP-1888063-B1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-01-14 | — | — | EP | disclosed |
| US-20080161302-A1 | N-(2-Methoxy-phenyl)-2-oxo-2-(2-phenyl-indolizin-3-yl)-acetamide; antifungal agents; inhibiting Aspergillus | F2G LTD. (GB) | 2008-07-03 | — | — | US | disclosed |
| EP-1888063-A1 | ANTIFUNGAL AGENTS | F2G Ltd. (GB) | 2008-02-20 | — | — | EP | disclosed |
| WO-2006123145-A1 | ANTIFUNGAL AGENTS | F2G LTD (GB) | 2006-11-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161302-A1 | N-(2-Methoxy-phenyl)-2-oxo-2-(2-phenyl-indolizin-3-yl)-acetamide; antifungal agents; inhibiting Aspergillus | NAT1, CYP1A2, CYP51A1 | SMN1; SMN2 3501/4885NPC1 1899/4885RAB9A 3669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.