Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.50 |
| ▸ | RELA | Q04206 | 3/20 | 0.45 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | AHR | P35869 | 1/20 | 0.38 |
| ▸ | TUBB1 | Q9H4B7 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 1/20 | 0.38 |
| ▸ | TTR | P02766 | 1/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13394314 | 0.84 | SMN1; SMN2 (0.45) | RELAMAPTTP53SMN1; SMN2MAOB | |
| SCHEMBL3305491 | 0.83 | SMN1; SMN2 (0.54) | RELAPADI4MAPTTP53SMN1; SMN2 | |
| SCHEMBL3305497 | 0.83 | SMN1; SMN2 (0.54) | RELAPADI4MAPTTP53SMN1; SMN2 | |
| SCHEMBL1850928 | 0.82 | NFE2L2 (0.50) | MAPTMAOBMAOAALDH1A1CYP19A1 | |
| SCHEMBL1850926 | 0.82 | NFE2L2 (0.50) | MAPTMAOBMAOAALDH1A1CYP19A1 | |
| SCHEMBL3306493 | 0.82 | SMN1; SMN2 (0.43) | HTR6MAPTTP53SMN1; SMN2AHR | |
| SCHEMBL3306489 | 0.82 | SMN1; SMN2 (0.43) | HTR6MAPTTP53SMN1; SMN2AHR | |
| SCHEMBL3307664 | 0.78 | SMN1; SMN2 (0.47) | ALOX5MAPTSMN1; SMN2THRBMAOB | |
| SCHEMBL3307658 | 0.78 | SMN1; SMN2 (0.47) | ALOX5MAPTSMN1; SMN2THRBMAOB | |
| SCHEMBL13394312 | 0.76 | NFE2L2 (0.51) | HTR6RELAALOX5MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8420052-B2 | Imaging agents useful for identifying AD pathology | SIEMENS MEDICAL SOLUTIONS USA, INC. (US) | 2013-04-16 | — | — | US | disclosed |