Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRD1 | P41143 | 10/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 5/20 | 0.52 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.52 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8253792 | 0.87 | OPRD1 (0.54) | OPRD1OPRM1OPRK1DPP4 | |
| SCHEMBL11065582 | 0.85 | OPRD1 (0.67) | OPRD1OPRM1OPRK1 | |
| SCHEMBL29351429 | 0.83 | ACE (0.59) | DPP4 | |
| SCHEMBL29657941 | 0.81 | CALCRL (0.57) | OPRD1OPRM1OPRK1SLC6A2 | |
| SCHEMBL31657795 | 0.80 | ACE (0.55) | DPP4 | |
| SCHEMBL29839269 | 0.79 | SLC6A2 (0.55) | OPRM1SLC6A2DPP4 | |
| SCHEMBL9052421 | 0.79 | SLC6A2 (0.63) | OPRD1OPRM1SLC6A2 | |
| SCHEMBL30503063 | 0.79 | SLC6A2 (0.53) | OPRD1OPRM1SLC6A2 | |
| SCHEMBL9053553 | 0.79 | SLC6A2 (0.63) | OPRD1OPRM1SLC6A2 | |
| SCHEMBL19215386 | 0.79 | DPP4 (0.45) | OPRM1SLC6A2DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2526942-B1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | UNIV NORTH CAROLINA CHAPEL HILL (US) | 2017-08-09 | — | — | EP | disclosed |
| US-9604907-B2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 2017-03-28 | — | — | US | disclosed |
| EP-2581440-B1 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | UNIV NORTH CAROLINA (US) | 2016-03-16 | — | — | EP | disclosed |
| EP-2581440-A2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | The University of North Carolina at Chapel Hill (US) | 2013-04-17 | — | — | EP | disclosed |
| EP-2526942-A2 | Methods of facilitating neural cell survival using non-peptide and peptide BDNF neurotrophin mimetics | The University of North Carolina at Chapel Hill (US) | 2012-11-28 | — | — | EP | disclosed |