Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 3/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.30 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.30 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4013156 | 0.90 | HRH4 (0.33) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4010173 | 0.89 | PDE4B (0.34) | PDE4BNPC1RAB9ACYP17A1CYP19A1 | |
| SCHEMBL4018297 | 0.85 | CYP17A1 (0.33) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4526001 | 0.82 | PDE4B (0.33) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4016579 | 0.82 | MAOA (0.33) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4163937 | 0.79 | MEN1 (0.38) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4525342 | 0.79 | USP7 (0.36) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL14856759 | 0.79 | PDE4B (0.34) | PDE4BKDM4ENPC1ALDH1A1LMNA | |
| SCHEMBL4011513 | 0.78 | CYP17A1 (0.32) | KDM4ENPC1ALDH1A1LMNAMAOA | |
| SCHEMBL4060696 | 0.77 | HRH4 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074106-B1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LAB LTD (IN) | 2013-04-17 | — | — | EP | disclosed |