Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP7 | Q93009 | 4/20 | 0.36 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CA9 | Q16790 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.31 |
| ▸ | SLC2A3 | P11169 | 1/20 | 0.31 |
| ▸ | OGA | O60502 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12316268 | 0.85 | HDAC9 (0.35) | USP7HDAC9CYP17A1CYP19A1CYP11B1 | |
| SCHEMBL4011513 | 0.82 | CYP17A1 (0.32) | CYP17A1CYP19A1CYP11B1CYP11B2CA9 | |
| SCHEMBL4013156 | 0.80 | HRH4 (0.33) | CYP17A1CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL4018297 | 0.79 | CYP17A1 (0.33) | HDAC9CYP17A1CYP19A1CYP11B1CYP11B2 | |
| SCHEMBL4526001 | 0.79 | PDE4B (0.33) | CYP17A1CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL4016579 | 0.79 | MAOA (0.33) | CYP17A1CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL14865178 | 0.79 | PDE4B (0.33) | CYP17A1CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL4012783 | 0.77 | MAOA (0.43) | CYP17A1CYP19A1CYP11B1CYP11B2KDM4E | |
| SCHEMBL4163937 | 0.77 | MEN1 (0.38) | CYP17A1CYP19A1CYP11B1CYP11B2CA9 | |
| SCHEMBL4013462 | 0.76 | MAOA (0.36) | CYP17A1CYP19A1CYP11B1CYP11B2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2074106-B1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LAB LTD (IN) | 2013-04-17 | — | — | EP | claimed |
| US-8263648-B2 | Diebenzofuran derivatives as inhibitors of PDE-4 and PDE-10 | Mylan Laboratories Ltd. (IN) | 2012-09-11 | — | — | US | claimed |
| US-20090281131-A1 | DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LABORATORIES LIMITED (IN) | 2009-11-12 | — | — | US | claimed |
| EP-2074106-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | Matrix Laboratories Limited (IN) | 2009-07-01 | — | — | EP | claimed |
| WO-2008032171-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MATRIX LABORATORIES LTD. (DE) | 2008-03-20 | — | — | WO | claimed |
| EP-2074106-B1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LAB LTD (IN) | 2013-04-17 | — | — | EP | disclosed |
| EP-2074106-B1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LAB LTD (IN) | 2013-04-17 | — | — | EP | disclosed |
| US-8263648-B2 | Diebenzofuran derivatives as inhibitors of PDE-4 and PDE-10 | Mylan Laboratories Ltd. (IN) | 2012-09-11 | — | — | US | disclosed |
| US-8263648-B2 | Diebenzofuran derivatives as inhibitors of PDE-4 and PDE-10 | Mylan Laboratories Ltd. (IN) | 2012-09-11 | — | — | US | disclosed |
| US-20090281131-A1 | DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LABORATORIES LIMITED (IN) | 2009-11-12 | — | — | US | disclosed |
| US-20090281131-A1 | DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MYLAN LABORATORIES LIMITED (IN) | 2009-11-12 | — | — | US | disclosed |
| WO-2008032171-A1 | DIBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | MATRIX LABORATORIES LTD. (DE) | 2008-03-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090281131-A1 | DIEBENZOFURAN DERIVATIVES AS INHIBITORS OF PDE-4 AND PDE-10 | PDE4A, PDE4B, PDE12 | USP7 1443/4885HDAC9 144/4885CYP17A1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.